Olivia Sorci1, Alexandra S Batzdorf1, Michael Mayer1, Sylvia Rhodes1, Matthew Peng1, Amanda R Jankelovits1, Julia N Hornyak1, Oke Gerke2, Poul Flemming Høilund-Carlsen2, Abass Alavi1, Chamith S Rajapakse3,4,5. 1. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. 2. Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. 3. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. chamith@pennmedicine.upenn.edu. 4. Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA. chamith@pennmedicine.upenn.edu. 5. MRI Education Center, 1 Founders Building, 3400 Spruce St., Philadelphia, PA, 19104, USA. chamith@pennmedicine.upenn.edu.
Abstract
AIMS: To investigate the benefit of utilizing 18F-sodium fluoride (NaF) PET/CT over calcium and Framingham scoring for potential preventative coronary artery disease (CAD) intervention. METHODS AND RESULTS: This retrospective study included 136 participants (ages 21-75, BMI 18-43 kg/m2): 86 healthy controls and 50 patients. CT heart segmentations were superimposed onto PET images and standard uptake values (SUV) were calculated by a semi-auto segmentation method of drawing volumes of interest around the heart. Intergroup comparisons were made matching 37 patient/control pairs based on age, gender, and BMI. ROC curves were generated to determine how well SUV and Framingham methods predicted patient status. Regressions including all 136 participants were performed between SUV, age, and BMI. Patients exhibited higher average SUV (SUVmean; P = 0.006) and Framingham scores (P = 0.02) than controls. However, ROC curves indicated that SUVmean could discriminate patients from controls (AUC = 0.63, P = 0.049), but Framingham scores could not (AUC = 0.44, P = 0.38). Calcium scores and maximum SUV (SUVmax) did not differ between patients and controls. SUVmean correlated with age and BMI among females (age, partial R2 = 0.16, P = 0.001; BMI, partial R2 = 0.12, P = 0.004) and males (age, partial R2 = 0.28, P < 0.0001; BMI, partial R2 = 0.22, P < 0.0001). CONCLUSION: Unlike calcium scores, NaF PET/CT-derived values differed between patients and controls. Framingham risk score patterns echoed those of SUVmean, but were not sensitive enough to predict patient status. SUVmean values increased with age and BMI. Therefore, incorporation of NaF PET/CT into routine prognostic CAD assessment might prove beneficial for assessing early stage plaque calcification in coronary arteries. TRIAL REGISTRATION: ClinicalTrials.gov (NCT01724749).
AIMS: To investigate the benefit of utilizing 18F-sodium fluoride (NaF) PET/CT over calcium and Framingham scoring for potential preventative coronary artery disease (CAD) intervention. METHODS AND RESULTS: This retrospective study included 136 participants (ages 21-75, BMI 18-43 kg/m2): 86 healthy controls and 50 patients. CT heart segmentations were superimposed onto PET images and standard uptake values (SUV) were calculated by a semi-auto segmentation method of drawing volumes of interest around the heart. Intergroup comparisons were made matching 37 patient/control pairs based on age, gender, and BMI. ROC curves were generated to determine how well SUV and Framingham methods predicted patient status. Regressions including all 136 participants were performed between SUV, age, and BMI. Patients exhibited higher average SUV (SUVmean; P = 0.006) and Framingham scores (P = 0.02) than controls. However, ROC curves indicated that SUVmean could discriminate patients from controls (AUC = 0.63, P = 0.049), but Framingham scores could not (AUC = 0.44, P = 0.38). Calcium scores and maximum SUV (SUVmax) did not differ between patients and controls. SUVmean correlated with age and BMI among females (age, partial R2 = 0.16, P = 0.001; BMI, partial R2 = 0.12, P = 0.004) and males (age, partial R2 = 0.28, P < 0.0001; BMI, partial R2 = 0.22, P < 0.0001). CONCLUSION: Unlike calcium scores, NaF PET/CT-derived values differed between patients and controls. Framingham risk score patterns echoed those of SUVmean, but were not sensitive enough to predict patient status. SUVmean values increased with age and BMI. Therefore, incorporation of NaF PET/CT into routine prognostic CAD assessment might prove beneficial for assessing early stage plaque calcification in coronary arteries. TRIAL REGISTRATION: ClinicalTrials.gov (NCT01724749).
Authors: Antonio Maria Sammartino; Raffaele Falco; Andrea Drera; Francesco Dondi; Pietro Bellini; Francesco Bertagna; Enrico Vizzardi Journal: Int J Cardiovasc Imaging Date: 2022-10-18 Impact factor: 2.316
Authors: Michael Mayer; Austin J Borja; Emily C Hancin; Thomas Auslander; Mona-Elisabeth Revheim; Mateen C Moghbel; Thomas J Werner; Abass Alavi; Chamith S Rajapakse Journal: Front Physiol Date: 2020-10-22 Impact factor: 4.566
Authors: Richard A P Takx; Ruth van Asperen; Jonas W Bartstra; Sabine R Zwakenberg; Jelmer M Wolterink; Csilla Celeng; Pim A de Jong; Joline W Beulens Journal: J Nucl Cardiol Date: 2020-03-17 Impact factor: 5.952