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Literature DB >> 31734149

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1.

Dinesh Raghu¹, Hai-Hui Xue², Lisa A Mielke³.

Abstract

T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

Entities: Disease Gene Species

Keywords: T cell; T cell factor-1; TCF-1; immunotherapy; innate lymphoid cell; stem cell-like memory; transcription factor

Year: 2019 PMID： 31734149 DOI： 10.1016/j.it.2019.10.006

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

Keyword Cloud
Cited

33 in total

1. Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands.

Authors: Brigette C Duckworth; Fanny Lafouresse; Verena C Wimmer; Benjamin J Broomfield; Lennard Dalit; Yannick O Alexandre; Amania A Sheikh; Raymond Z Qin; Carolina Alvarado; Lisa A Mielke; Marc Pellegrini; Scott N Mueller; Thomas Boudier; Kelly L Rogers; Joanna R Groom
Journal: Nat Immunol Date: 2021-03-01 Impact factor: 25.606

2. T_FH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function.

Authors: Fengyin Li; Xin Zhao; Yali Zhang; Peng Shao; Xiaoke Ma; William J Paradee; Chengyu Liu; Jianmin Wang; Hai-Hui Xue
Journal: Proc Natl Acad Sci U S A Date: 2021-01-12 Impact factor: 11.205

Review 3. T cell factor 1: A master regulator of the T cell response in disease.

Authors: Giulia Escobar; Davide Mangani; Ana C Anderson
Journal: Sci Immunol Date: 2020-11-06

4. Ectopic Tcf1 expression instills a stem-like program in exhausted CD8⁺ T cells to enhance viral and tumor immunity.

Authors: Qiang Shan; Sheng'en Hu; Xia Chen; Derek B Danahy; Vladimir P Badovinac; Chongzhi Zang; Hai-Hui Xue
Journal: Cell Mol Immunol Date: 2020-04-27 Impact factor: 11.530

Review 5. TCF1 in T cell immunity: a broadened frontier.

Authors: Xudong Zhao; Qiang Shan; Hai-Hui Xue
Journal: Nat Rev Immunol Date: 2021-06-14 Impact factor: 53.106

6. Inhibitory signaling sustains a distinct early memory CD8⁺ T cell precursor that is resistant to DNA damage.

Authors: Jonathan B Johnnidis; Yuki Muroyama; Shin Foong Ngiow; Zeyu Chen; Sasikanth Manne; Zhangying Cai; Shufei Song; Jesse M Platt; Jason M Schenkel; Mohamed Abdel-Hakeem; Jean-Christophe Beltra; Allison R Greenplate; Mohammed-Alkhatim A Ali; Kito Nzingha; Josephine R Giles; Christelle Harly; John Attanasio; Kristen E Pauken; Bertram Bengsch; Michael A Paley; Vesselin T Tomov; Makoto Kurachi; Dario A A Vignali; Arlene H Sharpe; Steven L Reiner; Avinash Bhandoola; F Bradley Johnson; E John Wherry
Journal: Sci Immunol Date: 2021-01-15

7. CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.

Authors: Sushil Kumar; Zexian Zeng; Archis Bagati; Rong En Tay; Lionel A Sanz; Stella R Hartono; Yoshinaga Ito; Fieda Abderazzaq; Elodie Hatchi; Peng Jiang; Adam N R Cartwright; Olamide Olawoyin; Nathan D Mathewson; Jason W Pyrdol; Mamie Z Li; John G Doench; Matthew A Booker; Michael Y Tolstorukov; Stephen J Elledge; Frédéric Chédin; X Shirley Liu; Kai W Wucherpfennig
Journal: Cancer Discov Date: 2021-03-11 Impact factor: 39.397