Dynamics and dietary risk assessment of thiamethoxam in wheat, lettuce and tomato using field experiments and computational simulation.

Thiamethoxam is a widely used pesticide applied to different field crops. To inform risk assessment for this pesticide across relevant crops, we usually rely on field trials, which require time, costs and energy. For providing reliable data across crops and reduce experimental efforts, field trials should be complemented with dynamic modelling. In the present work, we hence focused on combining field trials with dynamic modelling to simulate mass evolutions of the pesticide-plant-system for thiamethoxam applied to wheat, lettuce and tomato as three major food crops. Field trials were conducted with QuEChERS (quick, easy, cheap, effective, rugged and safe) liquid chromatography-mass spectrometry, which gave consistent maximum residue concentrations for thiamethoxam in wheat, lettuce and tomato. We used these residues to evaluate the related dietary risk of humans consuming these food crops. Our results indicated that thiamethoxam did not provide any unacceptable dietary risk for humans across these three food crops, which is in line with findings from previous studies. Results for the studied crops could be extrapolated to other crops and with that, our study constitutes a cost- and time-efficient way of providing reliable input for risk assessment of pesticides across crops, which is relevant for both practitioners and regulators.