Robert M Marron1, Maria Elena Vega Sanchez2, Heather Clauss3, A James Mamary2. 1. Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Electronic address: robert.marron@tuhs.temple.edu. 2. Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. 3. Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Abstract
BACKGROUND: Our case series describes three patients who have received single-lung transplantations for idiopathic pulmonary fibrosis (IPF) that develop cytomegalovirus (CMV) disease and hypoxemic respiratory failure with radiographic opacification of the native lung and sparing of the allograft. RESULTS: Hypoxemia resolved with treatment and with resolution of CMV viremia. Viral infections causing IPF exacerbations have been described in the literature, however, pulmonary CMV disease in single-lung transplant recipients has typically been observed as pneumonitis of the allograft. CONCLUSIONS: These clinical scenarios are consistent with acute exacerbation of native-lung IPF and subradiographic pneumonitis of the allograft caused by CMV disease.
BACKGROUND: Our case series describes three patients who have received single-lung transplantations for idiopathic pulmonary fibrosis (IPF) that develop cytomegalovirus (CMV) disease and hypoxemic respiratory failure with radiographic opacification of the native lung and sparing of the allograft. RESULTS:Hypoxemia resolved with treatment and with resolution of CMV viremia. Viral infections causing IPF exacerbations have been described in the literature, however, pulmonary CMV disease in single-lung transplant recipients has typically been observed as pneumonitis of the allograft. CONCLUSIONS: These clinical scenarios are consistent with acute exacerbation of native-lung IPF and subradiographic pneumonitis of the allograft caused by CMV disease.
Authors: Tiphaine Goletto; Sixtine Decaux; Vincent Bunel; Gaëlle Weisenburger; Jonathan Messika; Samer Najem; Chahine Medraoui; Cendrine Godet; Marie Pierre Debray; Brice Lortat-Jacob; Pierre Mordant; Yves Castier; Lila Bouadma; Raphael Borie; Hervé Mal Journal: J Med Case Rep Date: 2022-01-03