So Young Kim1, Chanyang Min2, Dong Jun Oh3, Hyo Geun Choi4. 1. Department of Otorhinolaryngology, Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. 2. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea; Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. 3. Department of Internal medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea; Department of Otorhinolaryngology, Head and Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea. Electronic address: pupen@naver.com.
Abstract
BACKGROUND: A relation between gastroesophageal reflux disease (GERD) and asthma has been suggested; however, causality has not been investigated. OBJECTIVE: This study aimed to delineate the causal relation between GERD and asthma. METHODS: Participants of the Korean National Health Insurance Service-National Sample Cohort 2002-2013 who were ≥20 years old were selected for this study. In study I, 116,502 patients with GERD were matched in a 1:2 ratio to 233,004 control I participants, and the hazard ratio (HR) of asthma in patients with GERD was analyzed. In study II, 104,146 patients with asthma were matched in a 1:1 ratio to 104,146 control II participants, and the HR for GERD in patients with asthma was analyzed. A stratified Cox-proportional hazards model was used. Subgroup analyses were performed according to age and sex. RESULTS: In study I, 12.5% (14,595 of 116,502) of the GERD group and 7.8% (18,135 of 233,004) of the control I group presented asthma (P < .001). The GERD group demonstrated a 1.46-fold higher HR for asthma than the control I group (95% confidence interval [CI] = 1.42-1.49, P < .001). In study II, 16.9% (17,582 of 104,146) of the asthma group and 11.9% (12,393 of 104,146) of the control II group presented GERD (P < .001). The asthma group showed a 1.36-fold higher HR for GERD than the control II group (95% CI = 1.33-1.39, P < .001). All age and sex subgroups presented consistent results. CONCLUSION: GERD and asthma had a bidirectional relation in the study population.
BACKGROUND: A relation between gastroesophageal reflux disease (GERD) and asthma has been suggested; however, causality has not been investigated. OBJECTIVE: This study aimed to delineate the causal relation between GERD and asthma. METHODS:Participants of the Korean National Health Insurance Service-National Sample Cohort 2002-2013 who were ≥20 years old were selected for this study. In study I, 116,502 patients with GERD were matched in a 1:2 ratio to 233,004 control I participants, and the hazard ratio (HR) of asthma in patients with GERD was analyzed. In study II, 104,146 patients with asthma were matched in a 1:1 ratio to 104,146 control II participants, and the HR for GERD in patients with asthma was analyzed. A stratified Cox-proportional hazards model was used. Subgroup analyses were performed according to age and sex. RESULTS: In study I, 12.5% (14,595 of 116,502) of the GERD group and 7.8% (18,135 of 233,004) of the control I group presented asthma (P < .001). The GERD group demonstrated a 1.46-fold higher HR for asthma than the control I group (95% confidence interval [CI] = 1.42-1.49, P < .001). In study II, 16.9% (17,582 of 104,146) of the asthma group and 11.9% (12,393 of 104,146) of the control II group presented GERD (P < .001). The asthma group showed a 1.36-fold higher HR for GERD than the control II group (95% CI = 1.33-1.39, P < .001). All age and sex subgroups presented consistent results. CONCLUSION:GERD and asthma had a bidirectional relation in the study population.
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