BACKGROUND: Increasing evidence suggests Bipolar Disorder (BD) to be frequently associated to a history of traumatic experiences and Post-traumatic Stress Disorder (PTSD), with consequent greater symptoms severity, number of hospitalizations and worsening in quality of life. The aim of the present study was to investigate the lifetime exposure to traumatic events and PTSD rates in-patients with BD and to analyze the relationships between PTSD symptoms, clinical characteristics and severity of the mood disorder. METHODS: A consecutive sample of 212 in-patients with a DSM-5 diagnosis of BD was enrolled at the psychiatric unit of a major University hospital in Italy and assessed by the SCID-5 and MOOD Spectrum-Self Report lifetime version (MOODS-SR). Socio-demographic characteristics, clinical features, substance or alcohol abuse, history of suicide related behaviors were also collected. RESULTS: Lifetime trauma exposure emerged in 72.3% subjects, with a DSM-5 PTSD diagnosis reported by 35.6%. Patients with PTSD showed more frequently a (hypo)manic episode at onset, alcohol or substance abuse, psychotic features, suicide behaviors, higher scores in almost all the MOODS-SR domains, compared to those without PTSD. LIMITATIONS: Cross sectional study. Lack of data about the time since trauma exposure or PTSD onset. CONCLUSIONS: Our findings show a history of multiple traumatic experiences in hospitalized patients with BD besides high rates of PTSD, with the co-occurrence of these conditions appearing to be related to a more severe BD. Detailed investigation of post-traumatic stress symptoms is recommended for the relevant implications on the choice of a tailored treatment and the prognosis assessment.
BACKGROUND: Increasing evidence suggests Bipolar Disorder (BD) to be frequently associated to a history of traumatic experiences and Post-traumatic Stress Disorder (PTSD), with consequent greater symptoms severity, number of hospitalizations and worsening in quality of life. The aim of the present study was to investigate the lifetime exposure to traumatic events and PTSD rates in-patients with BD and to analyze the relationships between PTSD symptoms, clinical characteristics and severity of the mood disorder. METHODS: A consecutive sample of 212 in-patients with a DSM-5 diagnosis of BD was enrolled at the psychiatric unit of a major University hospital in Italy and assessed by the SCID-5 and MOOD Spectrum-Self Report lifetime version (MOODS-SR). Socio-demographic characteristics, clinical features, substance or alcohol abuse, history of suicide related behaviors were also collected. RESULTS: Lifetime trauma exposure emerged in 72.3% subjects, with a DSM-5 PTSD diagnosis reported by 35.6%. Patients with PTSD showed more frequently a (hypo)manic episode at onset, alcohol or substance abuse, psychotic features, suicide behaviors, higher scores in almost all the MOODS-SR domains, compared to those without PTSD. LIMITATIONS: Cross sectional study. Lack of data about the time since trauma exposure or PTSD onset. CONCLUSIONS: Our findings show a history of multiple traumatic experiences in hospitalized patients with BD besides high rates of PTSD, with the co-occurrence of these conditions appearing to be related to a more severe BD. Detailed investigation of post-traumatic stress symptoms is recommended for the relevant implications on the choice of a tailored treatment and the prognosis assessment.
Authors: Claudia Carmassi; Carlo Antonio Bertelloni; Maria Teresa Avella; Ivan Cremone; Enrico Massimetti; Martina Corsi; Liliana Dell'Osso Journal: Clin Pract Epidemiol Ment Health Date: 2020-07-30
Authors: Claudia Carmassi; Eric Bui; Carlo A Bertelloni; Valerio Dell'Oste; Virginia Pedrinelli; Martina Corsi; Sigrid Baldanzi; Alfonso Cristaudo; Liliana Dell'Osso; Rodolfo Buselli Journal: Eur J Psychotraumatol Date: 2021-03-11
Authors: Claudia Carmassi; Claudia Foghi; Valerio Dell'Oste; Carlo Antonio Bertelloni; Andrea Fiorillo; Liliana Dell'Osso Journal: Int J Environ Res Public Health Date: 2020-08-13 Impact factor: 3.390
Authors: Claudia Carmassi; Valerio Dell'Oste; Claudia Foghi; Carlo Antonio Bertelloni; Eugenia Conti; Sara Calderoni; Roberta Battini; Liliana Dell'Osso Journal: Int J Environ Res Public Health Date: 2020-12-29 Impact factor: 3.390
Authors: Claudia Carmassi; Carlo Antonio Bertelloni; Valerio Dell'Oste; Chiara Luperini; Donatella Marazziti; Rodolfo Rossi; Liliana Dell'Osso Journal: Front Public Health Date: 2021-02-10
Authors: Catrin Lewis; Katie Lewis; Alice Roberts; Bethan Edwards; Claudia Evison; Ann John; Alan Meudell; Patrick Parry; Holly Pearce; Natalie Richards; Ian Jones; Jonathan I Bisson Journal: Acta Psychiatr Scand Date: 2022-07-13 Impact factor: 7.734