| Literature DB >> 3172979 |
Abstract
Lorazepam has been identified in the blood plasma of non-medicated rats by means of HPLC and gas chromatography combined with mass spectrometry. It was found to be present in about 1 ng per ml blood plasma. This pharmacologically highly active compound is the first dichlorinated benzodiazepine described to occur naturally in a tissue of mammals, not treated with benzodiazepines.Entities:
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Year: 1988 PMID： 3172979 DOI： 10.1016/0024-3205(88)90216-0
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037