Yue Lin1,2, Xiaojie Luo1, Lu Yu1,2, Yi Zhang3, Jinyuan Zhou4, Yuwei Jiang1, Chen Zhang1, Jintao Zhang1, Chunmei Li1, Min Chen1,2. 1. Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China. 2. Graduate School of Peking Union Medical College, Beijing 100730, China. 3. Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310058, China. 4. Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, preoperative grading of HCC is of great clinical significance. Amide proton transfer-weighted (APTw) imaging, as a novel contrast mechanism in the field of molecular imaging, provided new diagnostic ideas for the grading of HCC. METHODS: Between May 2017 and April 2018, 32 consecutive patients with pathologically confirmed HCC were enrolled, including 19 high-grade HCCs and 13 low-grade HCCs. DWI and APTw scanning was performed on a 3T MRI scanner. Two observers drew regions of interest independently by referring to the axial T2-weighted imaging, and APTw and apparent diffusion coefficient (ADC) values were obtained. Inter- and intra-observer agreements were assessed with the intraclass correlation coefficients (ICCs). The independent sample t test was used to compare the APTw and ADC values between the high- and low-grade HCC tumor parenchyma. The receiver operating characteristic curve was used to analyze the diagnostic efficacy of high- from low-grade HCC tumors. Spearman correlation analysis was used to assess the relationship between APTw and ADC values and HCC histological grades. RESULTS: There were significant differences between the APTw or ADC values for the high- and low-grade HCCs (P=0.034 and 0.010). Both APTw and DWI had good diagnostic performance in differentiating the high- from the low-grade HCCs, with areas under the curves of 0.814 and 0.745, respectively. Moderate correlations existed between APTw values and histological grades (r=0.534; P=0.002), as well as ADC values and histological grades (r=-0.417; P=0.018). CONCLUSIONS: The APTw imaging is a useful imaging biomarker that complements DWI for the more accurate and comprehensive HCC characterization. 2019 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, preoperative grading of HCC is of great clinical significance. Amide proton transfer-weighted (APTw) imaging, as a novel contrast mechanism in the field of molecular imaging, provided new diagnostic ideas for the grading of HCC. METHODS: Between May 2017 and April 2018, 32 consecutive patients with pathologically confirmed HCC were enrolled, including 19 high-grade HCCs and 13 low-grade HCCs. DWI and APTw scanning was performed on a 3T MRI scanner. Two observers drew regions of interest independently by referring to the axial T2-weighted imaging, and APTw and apparent diffusion coefficient (ADC) values were obtained. Inter- and intra-observer agreements were assessed with the intraclass correlation coefficients (ICCs). The independent sample t test was used to compare the APTw and ADC values between the high- and low-grade HCC tumor parenchyma. The receiver operating characteristic curve was used to analyze the diagnostic efficacy of high- from low-grade HCC tumors. Spearman correlation analysis was used to assess the relationship between APTw and ADC values and HCC histological grades. RESULTS: There were significant differences between the APTw or ADC values for the high- and low-grade HCCs (P=0.034 and 0.010). Both APTw and DWI had good diagnostic performance in differentiating the high- from the low-grade HCCs, with areas under the curves of 0.814 and 0.745, respectively. Moderate correlations existed between APTw values and histological grades (r=0.534; P=0.002), as well as ADC values and histological grades (r=-0.417; P=0.018). CONCLUSIONS: The APTw imaging is a useful imaging biomarker that complements DWI for the more accurate and comprehensive HCC characterization. 2019 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: Jing Yuan; Shuzhong Chen; Ann D King; Jinyuan Zhou; Kunwar S Bhatia; Qinwei Zhang; David Ka Wei Yeung; Juan Wei; Greta Seng Peng Mok; Yi-Xiang Wang Journal: NMR Biomed Date: 2014-08-19 Impact factor: 4.044
Authors: Benjamin King Hong Law; Ann D King; Qi-Yong Ai; Darren M C Poon; Weitian Chen; Kunwar S Bhatia; Anil T Ahuja; Brigette B Ma; David Ka-Wai Yeung; Frankie Kwok Fai Mo; Yi-Xiang Wang; Jing Yuan Journal: Radiology Date: 2018-06-12 Impact factor: 11.105
Authors: Jinyuan Zhou; Erik Tryggestad; Zhibo Wen; Bachchu Lal; Tingting Zhou; Rachel Grossman; Silun Wang; Kun Yan; De-Xue Fu; Eric Ford; Betty Tyler; Jaishri Blakeley; John Laterra; Peter C M van Zijl Journal: Nat Med Date: 2010-12-19 Impact factor: 53.440