Dear Editor, we read the publication on “Association of angiotensin-converting enzyme (AVE) G2350A gene polymorphisms with hypertension (HT) among patients with intracerebral haemorrhage”” with a great interest. Imran et al. concluded that “The A allele of the ACE gene polymorphisms is associated with hypertension among ICHpatients.” We would like to share ideas on the present report. In this article, the G to A variant was found for relationship with increased risk of HT. In fact, the important change due to ACEG2350A gene polymorphism is the molecular structure change. The change will result in alteration of molecular weight. Based on the molecular calculation method as published in the previous referencing studies,, the molecular weight change is equal to – 16 g/Mol (from in 151.13 g/Mol in G variant to 135.13 g/Mol to A variant). Therefore, the final expression will be more difficult in G variant or ACE level will be higher in A variant. This can further imply that A variant is more related to HT due to higher ACE level. This is the same process as observed in effect of genetic polymorphisms on other medical disorders.
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