| Literature DB >> 31727089 |
Hyo Keun Lee1,2, Se Ji Ahn1, Yang Mi Shin1, Nyeonju Kang3,4, James H Cauraugh5.
Abstract
In the original article [1], we mentioned that some study characteristics of the article by Dagan and colleagues [2] were unavailable.Entities:
Year: 2019 PMID: 31727089 PMCID: PMC6854778 DOI: 10.1186/s12984-019-0582-0
Source DB: PubMed Journal: J Neuroeng Rehabil ISSN: 1743-0003 Impact factor: 4.262
Participant characteristics
| Study | Total N | Age (yrs) | Gender | PD Duration (yrs) | UPDRS Part III at Baseline | Medication | DBS Treatment | FOG Test |
|---|---|---|---|---|---|---|---|---|
| Alizad [42] | 8 | NA | Total: 3F, 5 M | NA | NA | NA | NO | NA |
| Benninger [43] | 25 | Total: 63.9 ± 8.7 | Active: 4F, 9 M Sham: 5F, 7 M | Active: 10.6 ± 7.1 Sham: 9.1 ± 3.3 | Active: 22.2 ± 8.7 Sham: 17.5 ± 8.0 | On | NO | Patients with severe freezing or unable to walk 10 m were excluded |
| Capacci [44] | 7 | Total: 60.9 ± 9 | Total: 4F, 3 M | Total: 16.8 ± 4.0 | NA | NA | NO | NA |
| Costa-Ribeiro [45] | 22 | Active: 61.1 ± 9.1; Sham: 62.0 ± 16.7 | Active: 3F, 8 M Sham: 4F, 7 M | Active: 6.1 ± 3.8 Sham: 6.3 ± 3.7 | Active: 19.0 Sham: 19.1 | On | NO | FOG-Q(> 15 points) were excluded |
| Costa-Ribeiro [46] | 22 | Active: 61.1 ± 9.1 Sham: 62.0 ± 16.7 | Active: 3F, 8 M Sham: 4F, 7 M | Active: 6.1 ± 3.8 Sham: 6.3 ± 3.7 | Active: 19.0 ± 4.9 Sham: 17.6 ± 5.1 | On | NO | Patients were excluded when they presented severe freezing according the FOG-Q |
| Criminger [47] | 16 | Total: 68.1 ± 9.8 | Total: 4F, 12 M | Total: 8.7 ± 9.8 | Total: 23.4 ± 9.7 | On | NO | NA |
| da Silva [48] | 17 | Active: 66.0 ± 5.0 Sham: 66.0 ± 10.0 | Active: 4F, 4 M Sham: 3F, 6 M | Active: 6.0 ± 6.0 Sham: 5.0 ± 1.0 | NA | NA | NO | NA |
| Dagan [49] | 20 | Total: 68.8 ± 6.8 | Total: 17 M, 3 F | Total: 9.0 ± 5.7 | Total: 39.7 ± 14.6 | On | NO | FOG-Q: 20.5 ± 4.9 FOG-provoking test scores: 14.2 ± 8.00 |
| Fernández-Lago [50] | 18 | Total: 56.7 ± 11.6 | Total: 7F, 11 M | Total: 6.2 ± 3.7 | Total: 21.17 ± 11.3 | On | NO | NA |
| Kaski [51] | 16 | NA | NA | NA | NA | On | NO | Patients with severe freezing were excluded |
| Lattari [52] | 17 | Total: 67.2 ± 10.0 | Total: 4F, 13 M | Total: 7.1 ± 2.7 | Total: 18.0 ± 99.0 | On | NO | NA |
| Mak [53] | 18 | NA | NA | NA | NA | NA | NO | NA |
| Manenti [54] | 10 | Total: 67.1 ± 7.2 | Total: 4F, 6 M | Total: 8.1 ± 3.5 | Total: 13.3 ± 5.7 | On | NO | NA |
| Schabrun [55] | 16 | Active: 72.0 ± 4.9 Sham: 63.0 ± 11.0 | Active: 8 M Sham: 6F, 2 M | Active: 6.9 ± 4.4 Sham: 4.6 ± 3.9 | Active: 47.7 ± 7.5 Sham: 37.7 ± 9.8 | On | NO | NA |
| Swank [56] | 10 | Total: 68.7 ± 10.2 | Total: 2F, 8 M | Total: 7.9 ± 7.1 | Total: 37.0 ± 12.9 | On | NO | NA |
| Valentino [57] | 10 | Total: 72.3 ± 3.6 | Total: 5F, 5 M | Total: 11.0 ± 4.9 | Total: 32.0 ± 10.3 | On | NO | FOG-Q: 15.3 ± 2.7 |
| Verheyden [58] | 20 | NA | NA | Total: 9.0 ± 4.0 | Total: 16.0 ± 5.0 | On | NO | NA |
| Yotnuengnit [59] | 53 | Active: 68.2 ± 9.8 Sham: 62.7 ± 8.8 | Active: 6F, 11 M Sham: 6F, 12 M | Active: 9.4 ± 5.3 Sham: 6.6 ± 3.6 | Active: 11.9 ± 4.7 Sham: 11.2 ± 4.0 | On | NO | NA |
Note: Data for age and PD duration are mean ± standard deviation
Abbreviations: Active active tDCS protocols, DBS deep brain stimulation, F female, FOG Freezing of gait, FOG-Q Freezing of gait questionnaire, M male, NA not applicable, PD Duration time since PD diagnosis, UPDRS the Unified Parkinson’s Disease Rating Scale
tDCS protocols
| Study | Treatment | Session # | Active tDCS | Stimulation Site | Stimulation Parameters | Follow-Up Test |
|---|---|---|---|---|---|---|
| Alizad [42] | tDCS | 3 | A | M: Bi PMC & M1 | 1 mA, 20 min, 40 cm2 | No |
| Benninger [43] | tDCS | 8 | A | M: Bi PFC, PMC, & M1 (separately) | 2 mA, 20 min, 24.5 cm2 | Yes (12wks) |
| Capacci [44] | tDCS | 1 | A | M: Bi PFC (separately) | 2 mA, 20 min, NA | No |
| Costa-Ribeiro [45] | tDCS> | 10 | A | S: Central leg areas M1 (2 cm anterior to the vertex) | 2 mA, 13 min, NA | Yes (4wks) |
| Costa-Ribeiro [46] | tDCS> | 10 | A | S: Central leg areas M1 (2 cm anterior to the vertex) | 2 mA, 13 min, 35 cm2 | Yes (4wks) |
| Criminger [47] | tDCS | 3 | A&C | M: Bi DLPFC (A-tDCS on LH & C-tDCS on RH) | 2 mA, 20 min, 15 cm2 | No |
| da Silva [48] | tDCS | 1 | A | S: Central leg areas M1 & SMA | 2 mA, 15 min, 35 cm2 | No |
| Dagan [49] | tDCS | 2 | A | M: M1 & LH-DLPFC | 3 mA, 20 min, 3 cm2 | No |
| Fernández-Lago [50] | tDCS&TT | 1 | A | S: leg area M1 of AH | 2 mA, 20 min, 3.5 cm2 | No |
| Kaski [51] | tDCS&PT | 1 | A | S: Central leg areas M1 (10–20% anterior to the vertex) | 2 mA, 15 min, 40 cm2 | No |
| Lattari [52] | tDCS | 1 | A | S: LH DLPFC | 2 mA, 20 min, 35 cm2 | No |
| Mak [53] | tDCS | 5 | A | S: M1 | NA, 20 min, NA | No |
| Manenti [54] | tDCS | 2 | A | S: RH DLPFC | 2 mA, 7 min, 35 cm2 | No |
| Schabrun [55] | tDCS> | 9 | A | S: LH M1 | 2 mA, 20 min, 35 cm2 | Yes (12wks) |
| Swank [56] | tDCS | 1 | A&C | M: Bi DLPFC (A-tDCS on LH & C-tDCS on RH) | 2 mA, 20 min, NA | No |
| Valentino [57] | tDCS | 5 | A | S: Central leg areas M1 | 2 mA, 20 min, NA | Yes (4wks) |
| Verheyden [58] | tDCS | 1 | A | S: LH M1 | 1 mA, 15 min, NA | No |
| Yotnuengnit [59] | tDCS&PT | 6 | A | S: Central leg areas M1 | 2 mA, 30 min, 35 cm2 | Yes (8wks) |
Abbreviations: A anodal tDCS, AH affected hemisphere, Bi bilateral, C cathodal tDCS, DLPFC dorsolateral prefrontal cortex, GT gait training, LH left hemisphere, M multiple targeted brain regions, M1 primary motor cortex, NA not applicable, PFC prefrontal cortex, PMC premotor cortex, PT physical training, RH right hemisphere, S single targeted brain region, TT treadmill training, wks weeks (retention period)
PEDro score for methodological quality assessment
| Items | Alizad | Benninger | Capacci | Costa-Ribeiro | Costa-Ribeiro | Criminger | da Silva | Dagan | Fernandez-Lago | Kaski | Lattari | Mak | Manenti | Schabrun | Swank | Valentino | Verheyden | Yotnuengnit |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. Specific eligibility criteria | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| 2. Subjects random allocation | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 |
| 3. Allocation concealment | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
| 4. Similar groups at baseline | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 |
| 5. Blinding of all subjects | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| 6. Blinding of all therapists | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 7. Blinding of all assessors (at least one key outcome) | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
| 8. Data measurement from more than 85% of the subjects initially allocated to groups (at least one key outcome) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 9. All subjects received the treatment or control condition as allocated (at least one key outcome) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10. Between-group comparisons (at least one key outcome) | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
| 11. Point measures and measures of variability (at least one key outcome) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Total | 4 | 10 | 5 | 9 | 9 | 7 | 9 | 9 | 6 | 9 | 10 | 5 | 8 | 9 | 6 | 8 | 7 | 9 |
Fig. 2Cochrane risk of bias assessment. a Risk of bias summary and b Risk of bias graph