Chie Emoto1,2, Brooks T McPhail3, Tsuyoshi Fukuda1,2. 1. Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 2. Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio. 3. Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, South Carolina.