| Literature DB >> 31724738 |
Maryam Abolghasemi1,2, Sadra Samavarchi Tehrani3,4, Tooba Yousefi1,2, Ansar Karimian1,2, Ata Mahmoodpoor5, Aliakbar Ghamari5, Farhad Jadidi-Niaragh6, Mehdi Yousefi6, Hossein Samadi Kafil7, Milad Bastami6, Mahdi Edalati8, Shirin Eyvazi9, Mohsen Naghizadeh3,4, Niloufar Targhazeh10, Bahman Yousefi11, Amin Safa12, Maryam Majidinia13, Vahid Rameshknia11,14.
Abstract
Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor-κ B, phosphoinositide-3-kinase/Akt, and extracellular-signal-regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.Entities:
Keywords: biomarker; cancer; diagnosis; microRNAs; prognosis; signal pathway
Year: 2019 PMID： 31724738 DOI： 10.1002/jcp.29396
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384