Karol M Pencina1,2, Zhuoying Li2, Monty Montano1,2. 1. Harvard Medical School, Boston, Massachusetts. 2. Brigham and Women's Hospital, Boston, Massachusetts.
Abstract
BACKGROUND: The use of circulating clinically routine biomarkers and volitional physical activity using wristband accelerometry in preclinical middle-aged adults may provide sensitive measures of physical function and predict sooner the onset of age- and HIV-related physical decline. METHODS: Nested cross-sectional cohort study of adult men 50-65 years old with HIV infection on potent antiretroviral therapy and uninfected control participants within the Boston metropolitan area. Gait speed derived from wristband accelerometry, gait speed derived from a standardized 6-minute walk test, cellular immune biomarker levels (CD4 T cell, CD8 T cell), and serum anabolic biomarker levels (total and free testosterone, and sex-hormone-binding globulin) were measured. RESULTS: Of the five measured biomarkers, four were significantly associated with volitional gait speed based on accelerometry, whereas only one was associated with gait speed based on the 6-minute walk test collected in a laboratory environment. CONCLUSION: Levels of selected immune and anabolic biomarkers were associated with volitional physical activity in middle-aged individuals. Digital and circulating biomarkers may be useful in future studies designed to identify presymptomatic individuals at increased risk for age- and HIV-associated functional decline.
BACKGROUND: The use of circulating clinically routine biomarkers and volitional physical activity using wristband accelerometry in preclinical middle-aged adults may provide sensitive measures of physical function and predict sooner the onset of age- and HIV-related physical decline. METHODS: Nested cross-sectional cohort study of adult men 50-65 years old with HIV infection on potent antiretroviral therapy and uninfected control participants within the Boston metropolitan area. Gait speed derived from wristband accelerometry, gait speed derived from a standardized 6-minute walk test, cellular immune biomarker levels (CD4 T cell, CD8 T cell), and serum anabolic biomarker levels (total and free testosterone, and sex-hormone-binding globulin) were measured. RESULTS: Of the five measured biomarkers, four were significantly associated with volitional gait speed based on accelerometry, whereas only one was associated with gait speed based on the 6-minute walk test collected in a laboratory environment. CONCLUSION: Levels of selected immune and anabolic biomarkers were associated with volitional physical activity in middle-aged individuals. Digital and circulating biomarkers may be useful in future studies designed to identify presymptomatic individuals at increased risk for age- and HIV-associated functional decline.
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