Long-term extracorporeal membrane oxygenation after severe blunt traumatic lung injury in a child.

Managing acute respiratory distress syndrome (ARDS) after severe blunt traumatic lung injury can be challenging. In cases where patients are refractory to conventional therapy, extracorporeal membrane oxygenation (ECMO) should be considered. In addition, the heparin-coated circuit can reduce hemorrhagic complications in patients with multiple traumas. Although prolonged ECMO may be necessary, excellent outcomes are frequently associated. In this study, we report long-term support with venovenous-ECMO applied in a child with severe blunt trauma in Korea. This 10-year-old and 30 kg male with severe blunt thoracic trauma after a car accident developed severe ARDS a few days later, and ECMO was administered for 33 days. Because of pulmonary hemorrhage during ECMO support, heparin was stopped for 3 days and then restarted. He was weaned from ECMO successfully and has been able to run without difficulty for the 2 years since discharge.

Blunt thoracic injury is common in motor vehicle accidents and has a high mortality rate that accounts for 26% of deaths in children [1]. This can also result in acute respiratory distress syndrome (ARDS), which can be challenging to manage. Depending on the severity, mortality in these cases can be up to 30%-45% [2,3]. When a patient does not respond to conventional therapy, such as lung-protective mechanical ventilation, extracorporeal membrane oxygenation (ECMO) can be applied as a treatment option; its use has recently increased in patients with ARDS [4].

However, in cases of ARDS after traumatic injury, patients are at a high risk of severe bleeding during ECMO support because of systemic anticoagulation. The risk of hemorrhagic complications such as intracranial hemorrhage as well as surgical and cannular site bleeding is 40% in patients treated with venovenous (VV)-ECMO. Patients with recent major trauma and those undergoing damage-control interventions may have trauma-induced coagulopathy and higher bleeding risk [4]. ECMO has recently been used for patients with multiple traumas because it can reduce hemorrhagic complications with the development of ECMO technology and the application of a heparin-coated circuit [5].

Prolonged use of ECMO (>14 days) has been applied for respiratory failure and is associated with an increase in survival rates as high as 50%-70% to native lung recovery [6]. In this study, we discuss the case of a pediatric patient who recovered respiratory function after long-term use of VV-ECMO following a blunt crushing traumatic lung injury due to a traffic accident.

CASE REPORT

A 10-year-old, 30 kg male had severe blunt thoracic trauma after he was hit and his chest was run over by a car. On admission to the emergency room, he was alert but cyanotic (SpO2 58%) and dyspneic. His initial vital signs were blood pressure of 147/111 mmHg, heart rate of 160 beats/minute, respiratory rate (RR) of 40 breaths/minute, and a body temperature of 36℃. Initial arterial blood gas analysis (ABGA) revealed the following results: pH 7.167, PaCO2 55.6 mmHg, PaO2 40.3 mmHg, and HCO3- 18.7 mmol/L. Endotracheal bleeding was observed during intubation and mechanical ventilation was started. A bilateral closed thoracostomy was performed due to bilateral pneumothorax (Figure 1A, B). Extensive lung contusion of both lungs with a hemothorax, pneumothorax, pneumomediastinum, and fracture in the right first rib were indicated on chest computed tomography (Figure 1C). He showed acute respiratory distress syndrome based on PaO2/FiO2 (fraction of inspired oxygen)62. There was no injury on the head and neck, cardiovascular system or abdominal organs. His initial injury severity score was 25 and lung injury score was 15. His lung condition started to deteriorate on hospital day 9. Hypoxemia was not improved, with PaO2/FiO2 <100 in spite of 10 mmHg of positive end-expiratory pressure (PEEP) and 100% of FiO2. VV-ECMO was applied on hospital day 11 because oxygenation could not be maintained as PaO2/FiO2 99 despite 12 cm H2O PEEP (Figure 2). Oxygen Index was 18.2 right before ECMO implantation. High frequency of ventilator could not be applied because it was not available. For implantation of ECMO, vessel cannulation was performed with a 14-Fr Edward cannula in the left femoral vein and 14-Fr Biomedicus cannula in the right femoral vein. However, recirculation occurred right after ECMO support. A 14-Fr Edward arterial cannula was added in right internal jugular vein and then both femoral vein cannulas were used as drainage and the right jugular vein cannula was used as the return. A Maquet oxygenator was used for ECMO and blood flow was 3,300 ml/min, 1,940 revolutions per minute (rpm), with sweep gas 2 L/min (body surface area 0.68 kg/m2). Heparin was started with 150-160 seconds of activated clotting time (ACT). Thoracoscopic left lung repair and bleeding control were performed on VV-ECMO support. However, his pulmonary hemorrhage continued and his lung condition deteriorated to only 2.5 ml/kg of tidal volume (TV) with peak inspiratory pressure (PIP) 28 cm H2O. On day 7 of ECMO, the patient was transferred to a tertiary hospital. At the time of transfer, ECMO blood flow was 3,100 ml/min (2,120 rpm, sweep gas 4 L/min) and the ventilator setting was synchronized intermittent mandatory ventilation (SIMV) with pressure support (PS) mode (PS 13 cm H2O), FiO2 0.3, PEEP 12 cm H2O, TV 100 ml (3.4 ml/kg) and RR of 25 breaths/min. After transfer, heparin was stopped for 3 days because of pulmonary hemorrhage and red blood cells were transfused to the patient. The ventilator was set at pressure control mode, FiO2 0.4, PEEP 8 cm H2O, PIP 23 cm H2O, RR 20 breaths/min, and TV 75 ml (2.6 ml/kg). Heparin was restarted at a dosage of 10 U/kg/hr and then titrated with a target ACT of 150-180 seconds. No further pulmonary hemorrhage was observed. With physiotherapy including prone positioning and infection control for ventilator-associated pneumonia, the patient’s TV was increased to 4.5 ml/kg with a ventilator setting at SIMV and PS mode, PEEP 6 cm H2O, PIP 24 cm H2O, and RR 20 breaths/min on day 20 of ECMO. On day 29 of VV-ECMO, the TV was increased to 7 ml/kg in the SIMV and PS mode, with the lower PEEP and PIP at 5 cm H2O and 20 cm H2O, and RR 20 breaths/min. VV-ECMO was removed on day 33 of ECMO application. There were no complications related to ECMO cannulation except recirculation on initial ECMO support. Mechanical ventilation was weaned 6 days after ECMO removal. The patient was able to walk and was discharged 23 days after ECMO removal (hospital day 68) (Figure 3). Two years after the event, the patient was able to run without difficulty and had a mild restrictive pulmonary function test pattern, with a 62% forced vital capacity, 60% forced expiratory volume in 1 second, forced expiratory flow (FEF) 25%-75% of 73%, FEF 50% of 107%, and a peak expiratory flow of 94%.

Figure 1.

A Chest radiograph on admission. Bilateral pneumothorax and pneumomediastinum (A), and an image after bilateral closed thoracotomy (B). (C) Chest computed tomography on the day of admission. Extensive lung contusion of both lungs with left hemothorax, right pneumothorax, and pneumomediastinum.

Figure 2.

Chest radiograph on day 0 of extracorporeal membrane oxygenation.

Figure 3.

Chest radiograph 23 days after ECMO removal. ECMO: extracorporeal membrane oxygenation.

DISCUSSION

High impact traumas, such as motor vehicle or car accidents, are common causes of thoracic injuries in children [1]. Complications that follow severe trauma, such as ARDS, are associated with high mortality, with rates as high as 30%-45%, particularly in fulminant ARDS [2,3].

Managing ARDS after severe chest trauma remains a challenge. Patients with ARDS often require a prolonged stay in the intensive care unit and cases refractory to conventional therapy may require ECMO support [5].

ECMO is an intensive treatment that is used to support patients with respiratory or cardiac failure who are unresponsive to conventional therapy [2]. Because neonatal ECMO was associated with 81% survival rates (n = 715) when administered for respiratory failure in the 1980s [7], ECMO has been incorporated in adult patient therapy. A retrospective case review of the Extracorporeal Life Support Organization registry from 1986 to 2006 (n = 1,473) reported 50% survival to discharge of adult ECMO respiratory failure patients [8]. ECMO has currently become the standard treatment for cardiac and pulmonary failure that is unresponsive to other management in all age groups.

However, patients with ARDS after traumatic injury have high risk of severe bleeding related with systemic anticoagulation during treatment. Dismal outcomes are reported in multi-trauma patients who undergo emergency cardiopulmonary bypass because of uncontrollable bleeding from systemic heparinization [9]. Therefore, trauma injury was considered a contraindication for ECMO patients until the early 1990’s.

ECMO had been administered in patients with trauma injury since the 1990s [10,11] and has recently been used in patients with multiple traumas because of the reduction in hemorrhagic complications associated with the development of ECMO technology and the heparin-coated circuit [5]. In addition, the use of heparin-free ECMO could overcome the bleeding risk in multiple trauma patients with ECMO support. Some cases of non-heparinized ECMO support have been reported in patients with multiple traumas. Arlt et al. [12] reported the survival of six of 10 poly-traumatic patients with pulmonary or cardiopulmonary failure and hemorrhagic shock after application of initially heparin-free ECMO. After effective treatment of bleeding and signs of shock, low-dose heparin was applied to achieve an activated thromboplastin time (aPTT) of double the normal range or an ACT value above 150 sec [12]. Muellenbach et al. [13] reported three successful cases of initially heparin-free VV-ECMO in patients (16, 28, and 53 years old) with traumatic respiratory failure and severe traumatic brain injury. The heparin-free duration was 1-5 days and then low-dose heparin was started after successful hemorrhagic shock treatment, with a target aPTT of 40 to 50 seconds. The authors observed neither thromboembolic events nor unexpected clot formation in the extracorporeal circuit and oxygenator function was not restricted [13].

Long-term ECMO support was previously thought to be associated with unfavorable outcomes. However, advances in ECMO technology and critical care have allowed for successful long term ECMO support. Swaniker et al. [14] reported a 71% survival rate when ECMO was applied in 128 pediatric patients with respiratory failure due to pneumonia, ARDS and airway problems. This finding indicates that lung recovery occurs even in patients that receive ECMO for prolonged periods, and that the duration of ECMO does not correlate with survival. The longest ECMO run of 47 days was in a patient who survived with viral pneumonia. Renal failure, the need of inotropics, failure to return to dry weight and the absence of lung compliance improvement are factors associated with decreased survival on ECMO [14]. In pediatric trauma patients, VV-ECMO was used for support for 38 days in a 7-year-old patient with post-traumatic ARDS, and the patient regained a functionally normal lifestyle [15].

In our case, the patient was a 10-year-old male with severe ARDS after blunt chest trauma caused by a car accident. He had extensive lung contusion and was considered to be a high-risk case with a lung injury score of 15. We started ECMO on hospital day 11 because he did not respond to conventional treatment. Although the patient had pulmonary hemorrhage and ventilator-associated pneumonia, he was weaned successfully from ECMO after stopping heparin for 3 days and administering physiotherapy including prone positioning and infection control for ventilator-associated pneumonia. The total duration of ECMO was 33 days. The patient did not have complications related to ECMO cannulation except recirculation on initial ECMO support. The patient was discharged 23 days after ECMO removal. Two years after the event, he was able to run without difficulty.

Our case reports the successful prolonged use of ECMO in a pediatric patient with severe blunt chest trauma in Korea. The results indicate that excellent outcomes are possible for pediatric patients that are given prolonged, aggressive ECMO treatment over 30 days.