Literature DB >> 31723363

Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET.

Jieun Jeong1,2, Young Jin Jeong1,2, Kyung Won Park2,3, Do-Young Kang1,2.   

Abstract

PURPOSE: To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).
METHODS: We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50-70 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.
RESULTS: The distribution of amyloid beta for each brain region revealed no age-related trends (p > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).
CONCLUSIONS: We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease. © Korean Society of Nuclear Medicine 2019.

Entities:  

Keywords:  Alzheimer’s disease; F-18 florbetaben; Healthy; SUVR

Year:  2019        PMID： 31723363      PMCID： PMC6821903          DOI： 10.1007/s13139-019-00609-7

Source DB:  PubMed          Journal:  Nucl Med Mol Imaging        ISSN： 1869-3474


  10 in total

1.  Ethnic variability in dementia: results from Singapore.

Authors:  Encarnita R Ampil; Stephanie Fook-Chong; Swati N Sodagar; Christopher P L H Chen; Alexander P Auchus
Journal:  Alzheimer Dis Assoc Disord       Date:  2005 Oct-Dec       Impact factor: 2.703

2.  Optimizing Longitudinal Amyloid-β PET Measurement: The Challenges of Intensity Normalization.

Authors:  Susan M Landau
Journal:  J Nucl Med       Date:  2018-09-13       Impact factor: 10.057

3.  Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.

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Journal:  Lancet Neurol       Date:  2013-02       Impact factor: 44.182

4.  Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study.

Authors:  Henryk Barthel; Hermann-Josef Gertz; Stefan Dresel; Oliver Peters; Peter Bartenstein; Katharina Buerger; Florian Hiemeyer; Sabine M Wittemer-Rump; John Seibyl; Cornelia Reininger; Osama Sabri
Journal:  Lancet Neurol       Date:  2011-04-08       Impact factor: 44.182

5.  Evaluation of software tools for automated identification of neuroanatomical structures in quantitative β-amyloid PET imaging to diagnose Alzheimer's disease.

Authors:  Tobias Tuszynski; Michael Rullmann; Julia Luthardt; Daniel Butzke; Solveig Tiepolt; Hermann-Josef Gertz; Swen Hesse; Anita Seese; Donald Lobsien; Osama Sabri; Henryk Barthel
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-01-07       Impact factor: 9.236

6.  Amyloid-β associated cortical thinning in clinically normal elderly.

Authors:  J Alex Becker; Trey Hedden; Jeremy Carmasin; Jacqueline Maye; Dorene M Rentz; Deepti Putcha; Bruce Fischl; Douglas N Greve; Gad A Marshall; Stephen Salloway; Donald Marks; Randy L Buckner; Reisa A Sperling; Keith A Johnson
Journal:  Ann Neurol       Date:  2011-03-17       Impact factor: 10.422

Review 7.  Beta-amyloid imaging with florbetaben.

Authors:  Osama Sabri; John Seibyl; Christopher Rowe; Henryk Barthel
Journal:  Clin Transl Imaging       Date:  2015-02-12

8.  Low-dose CT for the spatial normalization of PET images: A validation procedure for amyloid-PET semi-quantification.

Authors:  Luca Presotto; Leonardo Iaccarino; Arianna Sala; Emilia G Vanoli; Cristina Muscio; Anna Nigri; Maria Grazia Bruzzone; Fabrizio Tagliavini; Luigi Gianolli; Daniela Perani; Valentino Bettinardi
Journal:  Neuroimage Clin       Date:  2018-07-19       Impact factor: 4.881

9.  Quantification of [(11)C]PIB PET for imaging myelin in the human brain: a test-retest reproducibility study in high-resolution research tomography.

Authors:  Mattia Veronese; Benedetta Bodini; Daniel García-Lorenzo; Marco Battaglini; Salvatore Bongarzone; Claude Comtat; Michel Bottlaender; Bruno Stankoff; Federico E Turkheimer
Journal:  J Cereb Blood Flow Metab       Date:  2015-06-10       Impact factor: 6.200

10.  Whole Brain Voxel-Wise Analysis of Cerebral Retention of Beta-Amyloid in Cognitively Normal Older Adults Using 18F-Florbetaben.

Authors:  Yoo Hyun Um; Woo Hee Choi; Won Sang Jung; Young Ha Park; Chang-Uk Lee; Hyun Kook Lim
Journal:  Psychiatry Investig       Date:  2017-11-07       Impact factor: 2.505
  10 in total
  1 in total

1.  Development of a Low-Molecular-Weight Aβ42 Detection System Using a Enzyme-Linked Peptide Assay.

Authors:  Sang-Heon Kim; Eun-Hye Lee; Hyung-Ji Kim; A-Ru Kim; Ye-Eun Kim; Jae-Hong Lee; Moon-Young Yoon; Seong-Ho Koh
Journal:  Biomolecules       Date:  2021-12-02
  1 in total

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