Literature DB >> 31720601

The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a.

Florian Nietzold1, Stefan Rubner, Thorsten Berg.   

Abstract

We present the first application of hydrophobic tagging to a non-covalent inhibitor of protein-protein interactions. Nutlin-3a-HT, created by fusing the hydrophobic tag HyT13 to the MDM2-p53 interaction inhibitor Nutlin-3a, prevented cellular accumulation of MDM2 upon p53 reactivation, and had a stronger effect on cell viability and the induction of apoptosis than Nutlin-3a.

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Year:  2019        PMID： 31720601     DOI： 10.1039/c9cc07795b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

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Journal:  J Biol Chem       Date:  2022-04-01       Impact factor: 5.486

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3.  Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1.

Authors:  So Ra Choi; Hee Myeong Wang; Min Hyeon Shin; Hyun-Suk Lim
Journal:  Int J Mol Sci       Date:  2021-06-15       Impact factor: 5.923

4.  Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway.

Authors:  Jianhao Xu; Liwei Ni; Fenglun Zhao; Xiaoxiao Dai; Jialong Tao; Jia Pan; Aiming Shi; Zhu Shen; Cunjin Su; Yusong Zhang
Journal:  Aging (Albany NY)       Date:  2021-02-17       Impact factor: 5.682
  4 in total

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