Zhida Wang1,2, Anna Marseglia2, Ying Shang2, Christina Dintica2, Cesare Patrone3, Weili Xu2,4. 1. NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital and Tianjin Endocrinology Institute, Tianjin Medical University, Tianjin, China. 2. Department Neurobiology, Aging Research Center, Care Sciences and Society (NVS), Karolinska Institutet and Stockholm University, Stockholm, Sweden. 3. Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Abstract
INTRODUCTION: The effect of comorbid cardiometabolic diseases (CMDs), including diabetes, heart diseases, and stroke, on dementia remains unclear. METHODS: A cohort of 2648 dementia-free adults aged ≥60 years was followed up for 12 years. An active lifestyle was defined in accordance with the engagement in leisure activities and/or a social network. Cox models were used in data analysis. RESULTS: The multiadjusted hazard ratio (HR, 95% confidence interval) of dementia was 1.41 (1.07-1.86) for one, 2.38 (1.58-3.59) for two, and 4.76 (2.04-11.13) for three CMDs. In joint exposure analysis, the HR of dementia was 3.36 (2.14-5.30) for participants with CMDs plus an inactive lifestyle and 1.32 (0.95-1.84) for those with CMDs plus an active lifestyle (reference: no CMDs plus active lifestyle). An active lifestyle delayed dementia onset by 3.50 years in people with CMDs. DISCUSSION: CMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk.
INTRODUCTION: The effect of comorbid cardiometabolic diseases (CMDs), including diabetes, heart diseases, and stroke, on dementia remains unclear. METHODS: A cohort of 2648 dementia-free adults aged ≥60 years was followed up for 12 years. An active lifestyle was defined in accordance with the engagement in leisure activities and/or a social network. Cox models were used in data analysis. RESULTS: The multiadjusted hazard ratio (HR, 95% confidence interval) of dementia was 1.41 (1.07-1.86) for one, 2.38 (1.58-3.59) for two, and 4.76 (2.04-11.13) for three CMDs. In joint exposure analysis, the HR of dementia was 3.36 (2.14-5.30) for participants with CMDs plus an inactive lifestyle and 1.32 (0.95-1.84) for those with CMDs plus an active lifestyle (reference: no CMDs plus active lifestyle). An active lifestyle delayed dementia onset by 3.50 years in people with CMDs. DISCUSSION: CMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk.
Authors: Rachel L Peterson; Kristen M George; Duyen Tran; Pallavi Malladi; Paola Gilsanz; Amy J H Kind; Rachel A Whitmer; Lilah M Besser; Oanh L Meyer Journal: Int J Environ Res Public Health Date: 2021-07-04 Impact factor: 4.614