OBJECTIVE: To describe the 2-year neurodevelopmental outcome in children with cerebral palsy associated with congenital Zika (CZ) and explore variables associated with a more severe presentation. METHODS: Data on 69 children with cerebral palsy associated with CZ, followed in a neurorehabilitation hospital, who consecutively attended the neurodevelopmental assessment at 2 years of age, were collected. Bayley III Scales of Infant and Toddler Development, Hammersmith Infant Neurological Examination, and Gross Motor Function Classification System were used for the outcome evaluation. Descriptive and inferential statistical analysis were performed. RESULTS: The median age at follow-up was of 24.0 (23-32) months. Only 3 (4.3%) children were not microcephalic. The majority presented with bilateral (94.2%), spastic (100.0%), Gross Motor Function Classification System grade IV or V (92.8%) cerebral palsy, epilepsy (73.1%), extremely low performances on cognitive (94.2%), language (95.7%), and motor (95.7%) Bayley-III Scales of Infant and Toddler Development Test scores. The median Hammersmith Infant Neurological Examination score was of 21.0 (range 9-75). There was a correlation between birth head circumference with the cognitive (r = 0.3, P < .01), language (r = 0.3, P < .01), and motor (r = 0.3, P < .01) Bayley-III Scales of Infant and Toddler Development Test scores, as well as with the Hammersmith Infant Neurological Examination score (r = 0.2, P < .03). An association was observed between an inferior median Hammersmith Infant Neurological Examination score with congenital microcephaly (P = .04), arthrogryposis (P = .02), and epilepsy in the first year (P < .01). CONCLUSION: Cerebral palsy related to CZ presents with a severe global impairment at a 2-year follow-up. Birth head circumference, arthrogryposis, and early epilepsy are associated with a worse outcome and may be considered as prognostic markers. These findings are important for the neurorehabilitation planning, parents' guiding, and future prognostic studies.
OBJECTIVE: To describe the 2-year neurodevelopmental outcome in children with cerebral palsy associated with congenital Zika (CZ) and explore variables associated with a more severe presentation. METHODS: Data on 69 children with cerebral palsy associated with CZ, followed in a neurorehabilitation hospital, who consecutively attended the neurodevelopmental assessment at 2 years of age, were collected. Bayley III Scales of Infant and Toddler Development, Hammersmith Infant Neurological Examination, and Gross Motor Function Classification System were used for the outcome evaluation. Descriptive and inferential statistical analysis were performed. RESULTS: The median age at follow-up was of 24.0 (23-32) months. Only 3 (4.3%) children were not microcephalic. The majority presented with bilateral (94.2%), spastic (100.0%), Gross Motor Function Classification System grade IV or V (92.8%) cerebral palsy, epilepsy (73.1%), extremely low performances on cognitive (94.2%), language (95.7%), and motor (95.7%) Bayley-III Scales of Infant and Toddler Development Test scores. The median Hammersmith Infant Neurological Examination score was of 21.0 (range 9-75). There was a correlation between birth head circumference with the cognitive (r = 0.3, P < .01), language (r = 0.3, P < .01), and motor (r = 0.3, P < .01) Bayley-III Scales of Infant and Toddler Development Test scores, as well as with the Hammersmith Infant Neurological Examination score (r = 0.2, P < .03). An association was observed between an inferior median Hammersmith Infant Neurological Examination score with congenital microcephaly (P = .04), arthrogryposis (P = .02), and epilepsy in the first year (P < .01). CONCLUSION:Cerebral palsy related to CZ presents with a severe global impairment at a 2-year follow-up. Birth head circumference, arthrogryposis, and early epilepsy are associated with a worse outcome and may be considered as prognostic markers. These findings are important for the neurorehabilitation planning, parents' guiding, and future prognostic studies.
Authors: Tatiana Hamanaka; Carla Trevisan M Ribeiro; Sheila Pone; Saint Clair Gomes; Karin Nielsen-Saines; Elizabeth B Brickley; Maria Elisabeth Moreira; Marcos Pone Journal: Viruses Date: 2022-05-28 Impact factor: 5.818
Authors: Antony Duttine; Tracey Smythe; Míriam Ribiero Calheiro de Sá; Silvia Ferrite; Maria Zuurmond; Maria Elisabeth Moreira; Anna Collins; Kate Milner; Hannah Kuper Journal: Int J Environ Res Public Health Date: 2020-05-19 Impact factor: 3.390
Authors: Lavinia Schüler Faccini; Luciana Friedrich; Sara Kvitko de Moura; Fernanda Diffini Santa Maria; Steice da Silva Inácio de Bone Journal: eNeurologicalSci Date: 2022-07-19
Authors: Danielle Maria da Silva Oliveira; Demócrito de Barros Miranda-Filho; Ricardo Arraes de Alencar Ximenes; Ulisses Ramos Montarroyos; Celina Maria Turchi Martelli; Elizabeth B Brickley; Mariana de Carvalho Leal Gouveia; Regina Coeli Ramos; Maria Ângela Wanderley Rocha; Thalia Velho Barreto de Araujo; Sophie Helena Eickmann; Laura Cunha Rodrigues; Jeyse Polliane de Oliveira Soares Bernardes; Maria Helena Teixeira Pinto; Karina Polo Norte Danda Soares; Claudia Marina Tavares de Araújo; Maria de Fátima Pessoa Militão-Albuquerque; Ana Célia Oliveira Dos Santos Journal: Dysphagia Date: 2020-09-04 Impact factor: 3.438
Authors: Marion Clé; Patrick Eldin; Laurence Briant; Annie Lannuzel; Yannick Simonin; Philippe Van de Perre; André Cabié; Sara Salinas Journal: J Neuroinflammation Date: 2020-08-10 Impact factor: 8.322