Elodie Bousquet1,2, Neha Khandelwal3, Marie Séminel1, Chadi Mehanna1,4, Sawsen Salah1, Pauline Eymard1, Slim Bodin Hassani1, Dominique Monnet1, Antoine Brezin1, Rupesh Agrawal3. 1. Department of Ophthalmology, Ophtalmopôle, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, AP-HP, Université Paris 5, Sorbonne Paris Cité, Paris, France. 2. Centre de Recherche des Cordeliers, INSERM U1138, Team 17, Université Paris Descartes Sorbonne Paris Cité, Paris, France. 3. National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore. 4. Department of Biostatistics, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
Abstract
Purpose: To assess the choroidal vascularity index (CVI) in birdshot chorioretinopathy (BSCR) patients. Methods: The CVI was calculated as the ratio of luminar area to the total subfoveal choroidal area on enhanced-depth imaging optical coherence tomography. Intraocular inflammation was defined by the presence of macular edema and/or vitritis and/or vasculitis and/or papillitis. Results: Eighty BSCR patients and 22 healthy controls were included. Foveal choroidal thickness was lower in the BSCR compared with the control group (p < 0.001). CVI was not different between the two groups. CVI was significantly higher in BSCR patients with inflammatory activity (p = 0.004). Using a multivariate linear regression model, longer disease duration was associated with lower CVI (p = 0.038), whereas the presence of papillitis was associated with a higher CVI (p = 0.003).Conclusions: The CVI was not different between the BSCR and the control group. However, the CVI may be used as a new tool for monitoring inflammatory activity in BSCR.
Purpose: To assess the choroidal vascularity index (CVI) in birdshot chorioretinopathy (BSCR) patients. Methods: The CVI was calculated as the ratio of luminar area to the total subfoveal choroidal area on enhanced-depth imaging optical coherence tomography. Intraocular inflammation was defined by the presence of macular edema and/or vitritis and/or vasculitis and/or papillitis. Results: Eighty BSCRpatients and 22 healthy controls were included. Foveal choroidal thickness was lower in the BSCR compared with the control group (p < 0.001). CVI was not different between the two groups. CVI was significantly higher in BSCRpatients with inflammatory activity (p = 0.004). Using a multivariate linear regression model, longer disease duration was associated with lower CVI (p = 0.038), whereas the presence of papillitis was associated with a higher CVI (p = 0.003).Conclusions: The CVI was not different between the BSCR and the control group. However, the CVI may be used as a new tool for monitoring inflammatory activity in BSCR.
Authors: Elodie Bousquet; Pierre Duraffour; Louis Debillon; Swathi Somisetty; Dominique Monnet; Antoine P Brézin Journal: J Clin Med Date: 2022-08-16 Impact factor: 4.964
Authors: Maximilian W M Wintergerst; Nicholas R Merten; Moritz Berger; Chantal Dysli; Jan H Terheyden; Enea Poletti; Frank G Holz; Valentin S Schäfer; Matthias Schmid; Thomas Ach; Robert P Finger Journal: Sci Rep Date: 2022-08-29 Impact factor: 4.996