Claudia Mendoza-Pinto1,2, Mario García-Carrasco3,4, Socorro Méndez-Martínez5, Tania Mogollán-Delfín1, Pamela Munguía-Realpozo1,2, Efrén Herrera-Robles6, Ivet Etchegaray-Morales7, José Luis Gálvez-Romero8,9, Álvaro Montiel-Jarquín10, Aurelio López-Colombo11. 1. Systemic Autoimmune Diseases Research Unit, Medical Unit of High Specialty, Manuel Ávila Camacho, National Medical Center-CIBIOR, Instituto Mexicano del Seguro Social, Calle 2 Norte 2004, Centro, 72000, Puebla, México. 2. Department of Immunology and Rheumatology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, México. 3. Systemic Autoimmune Diseases Research Unit, Medical Unit of High Specialty, Manuel Ávila Camacho, National Medical Center-CIBIOR, Instituto Mexicano del Seguro Social, Calle 2 Norte 2004, Centro, 72000, Puebla, México. mgc30591@yahoo.com. 4. Department of Immunology and Rheumatology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, México. mgc30591@yahoo.com. 5. Research Coordination, Instituto Mexicano del Seguro Social, Puebla, México. 6. Endoscopy Unit, Hospital de Especialidades, UMAE CMNMAC, Instituto Mexicano del Seguro Social, Puebla, México. 7. Physiotherapy Program, Medical School, Benemérita Universidad Autónoma de Puebla, Puebla, México. 8. Immunology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, México. 9. Immunology and Allergology Department, Instituto del Seguro Social al Servicio de los Trabajadores del Estado, Puebla, México. 10. Research in Health Coordination, UMAE CMNMAC, Instituto Mexicano del Seguro Social, Puebla, México. 11. Puebla Research Coordination, Highly Specialized Medical Unit, UMAE CMNMAC, Instituto Mexicano del Seguro Social, Puebla, México.
Abstract
OBJECTIVE: The aim of this study was to determine the frequency of Helicobacter pylori in SLE patients and to compare clinical characteristics and gastroduodenal lesions in patients with and without H. pylori infection. METHODS: Adult SLE patients were selected and subjected to endoscopy. Gastroduodenal lesions were examined by endoscopy and biopsy (antrum and corpus). Biopsies were evaluated by hematoxylin and eosin and Giemsa staining. Immunochromatographic membrane-based assay using amplification was used to test for H. pylori antigen (coproantigen) in stool samples in all participants. Clinical characteristics and gastroduodenal lesions were compared between patients with and without H. pylori infection. RESULTS: A total of 118 SLE patients were included (mean age 44.7 ± 11.7 years, mean disease duration 11.6 ± 6.0 years), of whom 101 (85.6%) were receiving non-steroidal anti-inflammatory drugs (NSAIDs). The coproantigen test was positive in 32 (27.1%) patients. H. pylori was present in twenty six patients (22.0%) in the gastric biopsy. The frequency of gastric erosions and gastric ulcers were 55.1% and 0.8%, respectively. Gastric erosions were less frequent in SLE patients with H. pylori infection than those without H. pylori (43.5.7% vs. 62.5%; p = 0.04). The age, disease duration, disease activity, chronic damage, gastroprotective drugs, and immunosuppressive therapy did not differ between the two groups. CONCLUSIONS: We found a high frequency of H. pylori infection in SLE patients. The severity of SLE and reception of gastroprotective therapy do not seem to be related to H. pylori infection. Immunosuppressive therapy may not be protective against H. pylori infection in SLE patients.Key Points• In patients with systemic lupus erythematosus (SLE), the frequency of Helicobacter pylori infection was 39% and gastric erosions were frequent.• Disease activity, chronic damage, gastroprotective drugs, and immunosuppressive therapy may not affect the prevalence of H. pylori infection in SLE patients.
OBJECTIVE: The aim of this study was to determine the frequency of Helicobacter pylori in SLE patients and to compare clinical characteristics and gastroduodenal lesions in patients with and without H. pylori infection. METHODS: Adult SLE patients were selected and subjected to endoscopy. Gastroduodenal lesions were examined by endoscopy and biopsy (antrum and corpus). Biopsies were evaluated by hematoxylin and eosin and Giemsa staining. Immunochromatographic membrane-based assay using amplification was used to test for H. pylori antigen (coproantigen) in stool samples in all participants. Clinical characteristics and gastroduodenal lesions were compared between patients with and without H. pylori infection. RESULTS: A total of 118 SLE patients were included (mean age 44.7 ± 11.7 years, mean disease duration 11.6 ± 6.0 years), of whom 101 (85.6%) were receiving non-steroidal anti-inflammatory drugs (NSAIDs). The coproantigen test was positive in 32 (27.1%) patients. H. pylori was present in twenty six patients (22.0%) in the gastric biopsy. The frequency of gastric erosions and gastric ulcers were 55.1% and 0.8%, respectively. Gastric erosions were less frequent in SLE patients with H. pylori infection than those without H. pylori (43.5.7% vs. 62.5%; p = 0.04). The age, disease duration, disease activity, chronic damage, gastroprotective drugs, and immunosuppressive therapy did not differ between the two groups. CONCLUSIONS: We found a high frequency of H. pylori infection in SLE patients. The severity of SLE and reception of gastroprotective therapy do not seem to be related to H. pylori infection. Immunosuppressive therapy may not be protective against H. pylori infection in SLE patients.Key Points• In patients with systemic lupus erythematosus (SLE), the frequency of Helicobacter pylori infection was 39% and gastric erosions were frequent.• Disease activity, chronic damage, gastroprotective drugs, and immunosuppressive therapy may not affect the prevalence of H. pylori infection in SLE patients.
Authors: Tatiana M Reshetnyak; Irina A Doroshkevich; Natalia V Seredavkina; Evgeny L Nasonov; Igor V Maev; Vasiliy I Reshetnyak Journal: Int J Rheumatol Date: 2019-05-05