Literature DB >> 31712218

Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution.

A Mizrahi1,2, J C Marvaud2, B Pilmis2,3, J C Nguyen Van4, C Couzigou3, C Bruel5, N Engrand6, A Le Monnier4,2, T Lambert4,2.   

Abstract

We report a case of a 62-year-old man treated for Streptococcus pneumoniae meningitis by ceftriaxone and dexamethasone. After neurological improvement, neurological degradation by vasculitis occurred, despite effective concentrations of ceftriaxone in the serum and cerebrospinal fluid (CSF). S. pneumoniae with increased MICs to third-generation-cephalosporins (3GC) was isolated from the ventricular fluid 10 days after the isolation of the first strain. Isolate analysis showed that a mutation in the penicillin-binding protein 2X (PBP2X) has occurred under treatment.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  3GC resistance; Streptococcus pneumoniae; meningitis; meningitis-related delayed cerebral injury; penicillin-binding protein; treatment failure

Mesh：

Substances：

Year:  2020        PMID： 31712218      PMCID： PMC7038270          DOI： 10.1128/AAC.01958-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae.

Authors:  R Muñoz; C G Dowson; M Daniels; T J Coffey; C Martin; R Hakenbeck; B G Spratt
Journal:  Mol Microbiol       Date:  1992-09       Impact factor: 3.501

2.  ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.

Authors:  D van de Beek; C Cabellos; O Dzupova; S Esposito; M Klein; A T Kloek; S L Leib; B Mourvillier; C Ostergaard; P Pagliano; H W Pfister; R C Read; O Resat Sipahi; M C Brouwer
Journal:  Clin Microbiol Infect       Date:  2016-04-07       Impact factor: 8.067

Review 3.  Treatment failure with use of a third-generation cephalosporin for penicillin-resistant pneumococcal meningitis: case report and review.

Authors:  C C John
Journal:  Clin Infect Dis       Date:  1994-02       Impact factor: 9.079

4.  Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series.

Authors:  Martijn Weisfelt; Diederik van de Beek; Lodewijk Spanjaard; Johannes B Reitsma; Jan de Gans
Journal:  Lancet Neurol       Date:  2006-02       Impact factor: 44.182

5.  2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis.

Authors:  Allan R Tunkel; Rodrigo Hasbun; Adarsh Bhimraj; Karin Byers; Sheldon L Kaplan; W Michael Scheld; Diederik van de Beek; Thomas P Bleck; Hugh J L Garton; Joseph R Zunt
Journal:  Clin Infect Dis       Date:  2017-03-15       Impact factor: 9.079

6.  Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors:  R Hakenbeck; M Tarpay; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1980-03       Impact factor: 5.191

Review 7.  Management of infections due to antibiotic-resistant Streptococcus pneumoniae.

Authors:  S L Kaplan; E O Mason
Journal:  Clin Microbiol Rev       Date:  1998-10       Impact factor: 26.132

8.  Delayed Cerebral Injury in Adults With Bacterial Meningitis: A Novel Complication of Adjunctive Steroids?

Authors:  Cinthia Gallegos; Farrell Tobolowsky; Masayuki Nigo; Rodrigo Hasbun
Journal:  Crit Care Med       Date:  2018-08       Impact factor: 7.598

9.  Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study.

Authors:  Edilane L Gouveia; Joice N Reis; Brendan Flannery; Soraia M Cordeiro; Josilene B T Lima; Ricardo M Pinheiro; Kátia Salgado; Ana Veronica Mascarenhas; M Gloria Carvalho; Bernard W Beall; Mitermayer G Reis; Albert I Ko
Journal:  BMC Infect Dis       Date:  2011-11-21       Impact factor: 3.090
  9 in total
  2 in total

1.  Case Commentary: Delayed Cerebral Vasculitis Associated with the Development of Ceftriaxone-Resistant Pneumococcal Meningitis.

Authors:  Rodrigo Hasbun
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

Review 2.  The contribution of nano-based strategies in overcoming ceftriaxone resistance: a literature review.

Authors:  Ashagrachew Tewabe; Tesfa Marew; Gebremariam Birhanu
Journal:  Pharmacol Res Perspect       Date:  2021-08
  2 in total

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