Literature DB >> 31712203

Efficacy of Bacteriophages in a Staphylococcus aureus Nondiabetic or Diabetic Foot Infection Murine Model.

S Albac1, M Medina2, D Labrousse1, D Hayez1, D Bonnot1, N Anzala1, F Laurent3, T Ferry4, A Dublanchet5, P Chavanet1,6, C Fevre2, D Croisier7.   

Abstract

This study investigated the in vivo efficacy of three bacteriophages combined compared with linezolid in two mouse models (nondiabetic and diabetic) of Staphylococcus aureus foot infection. In both models, a single injection of bacteriophages in the hindpaw showed significant antibacterial efficacy. Linezolid was as effective as bacteriophages in nondiabetic animals but ineffective in diabetic animals. These findings further support preclinical and clinical studies for the development of phage therapy.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Staphylococcus aureuszzm321990; bacteriophages; diabetic foot infection; preclinical drug studies

Mesh：

Substances：

Year:  2020        PMID： 31712203      PMCID： PMC6985754          DOI： 10.1128/AAC.01870-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes.

Authors:  Benjamin A Lipsky; Javier Aragón-Sánchez; Mathew Diggle; John Embil; Shigeo Kono; Lawrence Lavery; Éric Senneville; Vilma Urbančič-Rovan; Suzanne Van Asten; Edgar J G Peters
Journal:  Diabetes Metab Res Rev       Date:  2016-01       Impact factor: 4.876

2.  Linezolid tissue penetration and serum activity against strains of methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility in diabetic patients with foot infections.

Authors:  Gary E Stein; Sharon Schooley; Charles A Peloquin; Anne Missavage; Daniel H Havlichek
Journal:  J Antimicrob Chemother       Date:  2007-08-01       Impact factor: 5.790

3.  Effect of Cnidoscolus aconitifolius leaf extract on the blood glucose and insulin levels of inbred type 2 diabetic mice.

Authors:  F O Oladeinde; A M Kinyua; A A Laditan; R Michelin; J L Bryant; F Denaro; J M Makinde; A L Williams; A P Kennedy; Y Bronner
Journal:  Cell Mol Biol (Noisy-le-grand)       Date:  2007-05-15       Impact factor: 1.770

Review 4.  Factors associated with treatment failure in patients with diabetic foot infections: An analysis of data from randomized controlled trials.

Authors:  Konstantinos Z Vardakas; Maria Horianopoulou; Matthew E Falagas
Journal:  Diabetes Res Clin Pract       Date:  2008-03-04       Impact factor: 5.602

5.  Efficacy of bacteriophage therapy in experimental sepsis and meningitis caused by a clone O25b:H4-ST131 Escherichia coli strain producing CTX-M-15.

Authors:  Flavie Pouillot; Maryline Chomton; Hélène Blois; Celine Courroux; Julien Noelig; Philippe Bidet; Edouard Bingen; Stéphane Bonacorsi
Journal:  Antimicrob Agents Chemother       Date:  2012-04-09       Impact factor: 5.191

Review 6.  Linezolid pharmacokinetics and pharmacodynamics in clinical treatment.

Authors:  Matthew S Dryden
Journal:  J Antimicrob Chemother       Date:  2011-05       Impact factor: 5.790

Review 7.  Preventing foot ulcers in patients with diabetes.

Authors:  Nalini Singh; David G Armstrong; Benjamin A Lipsky
Journal:  JAMA       Date:  2005-01-12       Impact factor: 56.272

8.  Efficacy of the novel oxazolidinone compound FYL-67 for preventing biofilm formation by Staphylococcus aureus.

Authors:  Sisi Wu; Tao Yang; Youfu Luo; Xiaolu Li; Xian Zhang; Jianying Tang; Xiuying Ma; Zhenling Wang
Journal:  J Antimicrob Chemother       Date:  2014-07-04       Impact factor: 5.790

9.  Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections.

Authors:  Sanjay Chhibber; Tarsem Kaur
Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

10.  Salvage Debridement, Antibiotics and Implant Retention ("DAIR") With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?

Authors:  Tristan Ferry; Gilles Leboucher; Cindy Fevre; Yannick Herry; Anne Conrad; Jérôme Josse; Cécile Batailler; Christian Chidiac; Mathieu Medina; S Lustig; Frédéric Laurent
Journal:  Open Forum Infect Dis       Date:  2018-10-24       Impact factor: 3.835
  10 in total
  3 in total

Review 1.  Bacteriophage Therapy for Staphylococcus Aureus Infections: A Review of Animal Models, Treatments, and Clinical Trials.

Authors:  Lucile Plumet; Nour Ahmad-Mansour; Catherine Dunyach-Remy; Karima Kissa; Albert Sotto; Jean-Philippe Lavigne; Denis Costechareyre; Virginie Molle
Journal:  Front Cell Infect Microbiol       Date:  2022-06-17       Impact factor: 6.073

2.  Characterization of a Novel Bacteriophage Henu2 and Evaluation of the Synergistic Antibacterial Activity of Phage-Antibiotics.

Authors:  Xianghui Li; Tongxin Hu; Jiacun Wei; Yuhua He; Abualgasim Elgaili Abdalla; Guoying Wang; Yanzhang Li; Tieshan Teng
Journal:  Antibiotics (Basel)       Date:  2021-02-09

Review 3.  Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection.

Authors:  Tristan Ferry; Camille Kolenda; Thomas Briot; Aubin Souche; Sébastien Lustig; Jérôme Josse; Cécile Batailler; Fabrice Pirot; Mathieu Medina; Gilles Leboucher; Frédéric Laurent
Journal:  Viruses       Date:  2021-12-02       Impact factor: 5.048
  3 in total

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