Aman Sharma1, Sarah Baker2, Marloes Duijm3, Esther Oomen-de Hoop3, Robin Cornelissen4, Cornelis Verhoef5, Mischa Hoogeman3, Joost Jan Nuyttens3. 1. Department of Radiotherapy & Oncology, Regional Cancer Centre, Indira Gandhi Medical College, Shimla, India. Electronic address: amans757@gmail.com. 2. Department of Radiation Oncology, British Columbia Cancer Agency - Surrey Centre, Canada. 3. Department of Radiation Oncology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands. 4. Department of Pulmonology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands. 5. Department of Surgical Oncology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands.
Abstract
PURPOSE: The study aimed to evaluate overall survival and local control, and to identify factors independently associated with overall survival (OS) and local control (LC). MATERIALS AND METHODS: This retrospective study examined 118 patients with primary colorectal cancer, in whom 202 inoperable pulmonary oligometastases were treated with stereotactic body radiotherapy between 2005 and 2015. Primary endpoint was to evaluate OS and identify prognostic factors associated with OS. Secondary aim was to evaluate LC and identify prognostic factors associated with LC. RESULTS: Median follow-up was 31 months (range 3-88 months). Median OS was 39.2 months (95% CI 34.8-43.6 months). Two-, three-, and five-year OS was 69%, 55% and 36%, respectively. LC at 2-, 3-, and 5-year was 83%, 81% and 77% respectively. Factors independently associated with OS in the multivariable analysis included BED10 ≥ 100 Gy (HR 0.52), male gender (HR 0.52), age < 70 years (HR 0.52) and presence of single metastasis (HR 0.37). BED10 < 100 Gy (HR 3.67) and pre-SBRT chemotherapy (HR 2.66) were independently associated with poor LC in a multivariable analysis. CONCLUSIONS: SBRT was associated with 2- year OS of 69% and 2-year LC of 83%. SBRT dose ≥ 100 Gy BED10 was independently associated with both better overall survival and local control.
PURPOSE: The study aimed to evaluate overall survival and local control, and to identify factors independently associated with overall survival (OS) and local control (LC). MATERIALS AND METHODS: This retrospective study examined 118 patients with primary colorectal cancer, in whom 202 inoperable pulmonary oligometastases were treated with stereotactic body radiotherapy between 2005 and 2015. Primary endpoint was to evaluate OS and identify prognostic factors associated with OS. Secondary aim was to evaluate LC and identify prognostic factors associated with LC. RESULTS: Median follow-up was 31 months (range 3-88 months). Median OS was 39.2 months (95% CI 34.8-43.6 months). Two-, three-, and five-year OS was 69%, 55% and 36%, respectively. LC at 2-, 3-, and 5-year was 83%, 81% and 77% respectively. Factors independently associated with OS in the multivariable analysis included BED10 ≥ 100 Gy (HR 0.52), male gender (HR 0.52), age < 70 years (HR 0.52) and presence of single metastasis (HR 0.37). BED10 < 100 Gy (HR 3.67) and pre-SBRT chemotherapy (HR 2.66) were independently associated with poor LC in a multivariable analysis. CONCLUSIONS: SBRT was associated with 2- year OS of 69% and 2-year LC of 83%. SBRT dose ≥ 100 Gy BED10 was independently associated with both better overall survival and local control.