Literature DB >> 31710246

Combination of G2-S16 dendrimer/dapivirine antiretroviral as a new HIV-1 microbicide.

Carlos Guerrero-Beltrán1,2, AnabeI Prieto3, Manuel Leal3, José Luis Jiménez2,4, M Ángeles Muñoz-Fernández1,2,4.   

Abstract

Aim: To research the synergistic activity of G2-S16 dendrimer and dapivirine (DPV) antiretroviral as microbicide candidate to prevent HIV-1 infection. Materials & methods: We assess the toxicity of DPV on cell lines by MTT assay, the anti-HIV-1 activity of G2-S16 and DPV alone or combined at several fixed ratios. Finally, their ability to inhibit the bacterial growth in vitro was assayed. The analysis of combinatorial effects and the effective concentrations were performed with CalcuSyn software.
Conclusion: Our results represent the first proof-of-concept study of G2-S16/DPV combination to develop a safe microbicide.

Entities:  

Keywords:  G2-S16 dendrimer; HIV-1; dapivirine; microbicide

Year:  2019        PMID： 31710246     DOI： 10.4155/fmc-2018-0539

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  5 in total

Review 1.  Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides.

Authors:  Ignacio Rodríguez-Izquierdo; Daniel Sepúlveda-Crespo; Jose María Lasso; Salvador Resino; Ma Ángeles Muñoz-Fernández
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2022-01-12

Review 2.  High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection.

Authors:  Ignacio Rodriguez-Izquierdo; Samanta Gasco; Maria Angeles Muñoz-Fernández
Journal:  Molecules       Date:  2020-06-28       Impact factor: 4.411

Review 3.  Emergence of Nanotechnology to Fight HIV Sexual Transmission: The Trip of G2-S16 Polyanionic Carbosilane Dendrimer to Possible Pre-Clinical Trials.

Authors:  Ignacio Relaño-Rodríguez; Maria Ángeles Muñoz-Fernández
Journal:  Int J Mol Sci       Date:  2020-12-10       Impact factor: 5.923

4.  Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide.

Authors:  Alba Martin-Moreno; Rafael Ceña-Diez; María Jesús Serramía; José Luis Jiménez; Rafael Gómez-Ramírez; Mariángeles Muñoz-Fernández
Journal:  Int J Mol Sci       Date:  2022-02-25       Impact factor: 5.923

5.  Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers.

Authors:  Elena Royo-Rubio; Vanessa Martín-Cañadilla; Marco Rusnati; Maria Milanesi; Tania Lozano-Cruz; Rafael Gómez; José Luís Jiménez; Maria Ángeles Muñoz-Fernández
Journal:  Pharmaceutics       Date:  2022-02-28       Impact factor: 6.321
  5 in total

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