Literature DB >> 317098

Carbon-11-labeled amino acids for the rectilinear and positron tomographic imaging of the human pancreas.

K F Hübner, G A Andrews, E Buonocore, R L Hayes, L C Washburn, I R Collmann, W D Gibbs.   

Abstract

Modification of the Bücherer-Strecker amino acid synthesis facilitated the production of DL-[11C]tryptophan and DL-[11C]valine for clinical trials in patients with proven or suspected pancreatic disease. Examples of rectilinear scans and tomographic images of the pancreas are presented in this initial paper. Positron computed tomography was done with the ORTEC ECAT system. Rapid localization of these C-11-labeled amino acids and fast clearance from the plasma permit almost immediate examination following i.v. injection. Illustrative images include the normal pancreas, pancreatitis, and pancreatic carcinoma. The use of positron tomobraphy with C-11-labeled DL-tryptophan and DL-valine appears to offer a new and promising diagnostic modality for the detection and study of pancreatic diseases.

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Year:  1979        PMID： 317098

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  10 in total

1.  Estimates of the effective dose equivalent, HE, in positron emission tomography studies.

Authors:  W Huda; G A Sandison
Journal:  Eur J Nucl Med       Date:  1990

Review 2.  Novel Approaches to Imaging Tumor Metabolism.

Authors:  Sui-Seng Tee; Kayvan R Keshari
Journal:  Cancer J       Date:  2015 May-Jun       Impact factor: 3.360

Review 3.  From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application.

Authors:  Aleksandra Pekošak; Ulrike Filp; Alex J Poot; Albert D Windhorst
Journal:  Mol Imaging Biol       Date:  2018-08       Impact factor: 3.488

4.  High-Yielding Automated Convergent Synthesis of No-Carrier-Added [11C-Carbonyl]-Labeled Amino Acids Using the Strecker Reaction.

Authors:  Junhao Xing; Allen F Brooks; Dylan Fink; Huibin Zhang; Morand R Piert; Peter J H Scott; Xia Shao
Journal:  Synlett       Date:  2016-11-07       Impact factor: 2.454

5.  Fluorine-18-Labeled PET Radiotracers for Imaging Tryptophan Uptake and Metabolism: a Systematic Review.

Authors:  Flóra John; Otto Muzik; Sandeep Mittal; Csaba Juhász
Journal:  Mol Imaging Biol       Date:  2020-08       Impact factor: 3.488

6.  High reactivity of [11C]CH3I with thiol group in the synthesis of C-11 labeled radiopharmaceuticals.

Authors:  Y Magata; H Saji; T Tokui; Y Ohmomo; Y Yamada; M Hirata; J Konishi; A Yokoyama
Journal:  Ann Nucl Med       Date:  1993-08       Impact factor: 2.668

7.  Fluorodeoxyglucose positron emission tomography in pancreatic cancer: an unsolved problem.

Authors:  T Kato; H Fukatsu; K Ito; M Tadokoro; T Ota; M Ikeda; T Isomura; S Ito; M Nishino; T Ishigaki
Journal:  Eur J Nucl Med       Date:  1995-01

8.  PET radiopharmaceuticals in Europe: current use and data relevant for the formulation of summaries of product characteristics (SPCs).

Authors:  G J Meyer; S L Waters; H H Coenen; A Luxen; B Maziere; B Langström
Journal:  Eur J Nucl Med       Date:  1995-12

9.  Experimental pancreas imaging study with 13N-glutamate using positron computer tomography.

Authors:  K Kubota; H Fukuda; K Yamada; S Endo; M Ito; Y Abe; T Yamaguchi; T Fujiwara; T Sato; H Yamaura
Journal:  Eur J Nucl Med       Date:  1983

Review 10.  Comparison of amino acid positron emission tomographic radiotracers for molecular imaging of primary and metastatic brain tumors.

Authors:  Csaba Juhász; Shalini Dwivedi; David O Kamson; Sharon K Michelhaugh; Sandeep Mittal
Journal:  Mol Imaging       Date:  2014       Impact factor: 4.488
  10 in total

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