A Prigitano1, C Cavanna2, M Passera3, M Gelmi4, E Sala5, C Ossi6, A Grancini7, M Calabrò8, S Bramati9, M Tejada10, F Lallitto2, C Farina3, V Rognoni11, M A Fasano12, B Pini13, L Romanò1, M Cogliati1, M C Esposto1, A M Tortorano14. 1. Department of Biomedical Science for Health, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy. 2. Microbiology and Virology Unit IRCCS Policlinico San Matteo, Pavia, Italy. 3. Microbiology Institute, ASST 'Papa G iovanni XXIII', Bergamo, Italy. 4. Microbiology Laboratory, A.O. Spedali Civili, Brescia, Italy. 5. Microbiology - ASST Lariana, Como, Italy. 6. Laboratory of Microbiology and Virology, San Raffaele Scientific Institute, Milano, Italy. 7. Microbiology Laboratory, Fondazione IRCCS C à Granda O. Maggiore Policlinico, Milano, Italy. 8. Microbiology Section, Humanitas Research Hospital, Milano, Italy. 9. Microbiology Laboratory, Ospedale San Gerardo, Monza, Italy. 10. Medicina di Laboratorio, IRCCS Policlinico San Donato, Milano, Italy. 11. Microbiology Unit, ASST Lodi, Italy. 12. Microbiology and Virology Unit, ASST Bergamo Ovest Treviglio, Italy. 13. Laboratory of Microbiology and Virology, ASST Lecco, Italy. 14. Department of Biomedical Science for Health, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy. Electronic address: annamaria.tortorano@unimi.it.
Abstract
BACKGROUND: Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy. METHODS: Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016-2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed. RESULTS: A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins<2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC. CONCLUSIONS: No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.
BACKGROUND:Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy. METHODS: Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016-2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed. RESULTS: A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins<2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC. CONCLUSIONS: No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.
Authors: Konstantin A Demin; Aleksandr G Refeld; Anna A Bogdanova; Evgenya V Prazdnova; Igor V Popov; Olga Yu Kutsevalova; Alexey M Ermakov; Anzhelica B Bren; Dmitry V Rudoy; Vladimir A Chistyakov; Richard Weeks; Michael L Chikindas Journal: Probiotics Antimicrob Proteins Date: 2021-03-18 Impact factor: 4.609
Authors: Anna Maria Tortorano; Anna Prigitano; Gianluca Morroni; Lucia Brescini; Francesco Barchiesi Journal: Infect Drug Resist Date: 2021-12-19 Impact factor: 4.003
Authors: Kostas Koutsoumanis; Ana Allende; Avelino Alvarez-Ordóñez; Declan Bolton; Sara Bover-Cid; Marianne Chemaly; Robert Davies; Alessandra De Cesare; Friederike Hilbert; Roland Lindqvist; Maarten Nauta; Luisa Peixe; Giuseppe Ru; Marion Simmons; Panagiotis Skandamis; Elisabetta Suffredini; Pier Sandro Cocconcelli; Pablo Salvador Fernández Escámez; Miguel Prieto-Maradona; Amparo Querol; Lolke Sijtsma; Juan Evaristo Suarez; Ingvar Sundh; Just Vlak; Fulvio Barizzone; Michaela Hempen; Lieve Herman Journal: EFSA J Date: 2021-07-07