| Literature DB >> 31708357 |
Kianoush Kashani1, Mitchell H Rosner2, Marlies Ostermann3.
Abstract
Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided.Entities:
Keywords: Creatine; Creatinine; Cystatin C; GFR; Kidney function; Muscle mass; Sarcopenia
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Year: 2019 PMID： 31708357 DOI： 10.1016/j.ejim.2019.10.025
Source DB: PubMed Journal: Eur J Intern Med ISSN： 0953-6205 Impact factor: 4.487