Literature DB >> 3170773

Prognostic indicators in centroblastic-centrocytic lymphoma.

N R Griffin1, M R Howard, P Quirke, C J O'Brien, J A Child, C C Bird.   

Abstract

The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.

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Year:  1988        PMID： 3170773      PMCID： PMC1141617          DOI： 10.1136/jcp.41.8.866

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  31 in total

1.  Morphologic classification of non-Hodgkin's lymphoma. I. Retrospective analysis using the Kiel classification.

Authors:  B Glimelius; C Sundström
Journal:  Acta Radiol Oncol       Date:  1982

2.  Yorkshire Regional Lymphoma Histopathology panel: analysis of five years' experience.

Authors:  C C Bird; I Lauder; H S Kellett; I Chorlton; N Barnes; C Darwin; R A Cartwright; R Boyko
Journal:  J Pathol       Date:  1984-08       Impact factor: 7.996

3.  Non-Hodgkin malignant lymphomas. Clinico-pathologic correlations with the Kiel classification. Retrospective analysis of a series of 274 cases.

Authors:  C Meugé; B Hoerni; A de Mascarel; M Durand; P Richaud; G Hoerni-Simon; J Chauvergne; C Lagarde
Journal:  Eur J Cancer       Date:  1978-05       Impact factor: 9.162

Review 4.  Clinical and prognostic relevance of the Kiel classification of non-Hodgkin lymphomas results of a prospective multicenter study by the Kiel Lymphoma Study Group.

Authors:  G Brittinger; H Bartels; H Common; E Dühmke; H H Fülle; U Gunzer; T Gyenes; R Heinz; E König; P Meusers
Journal:  Hematol Oncol       Date:  1984 Jul-Sep       Impact factor: 5.271

5.  Proliferation kinetics of malignant non-Hodgkin's lymphomas related to histopathology of lymph node biopsies.

Authors:  W Lang; S Kienzle; V Diehl
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1980

6.  Morphologic types of diffuse large-cell lymphoma.

Authors:  R A Warnke; J A Strauchen; J S Burke; R T Hoppe; B A Campbell; R F Dorfman
Journal:  Cancer       Date:  1982-08-15       Impact factor: 6.860

7.  Flow cytometry in the diagnosis and classification of malignant lymphoma and leukemia.

Authors:  L W Diamond; B N Nathwani; H Rappaport
Journal:  Cancer       Date:  1982-09-15       Impact factor: 6.860

8.  Malignant lymphoma, small lymphocytic type: a clinicopathologic study of 84 cases with suggested criteria for intermediate lymphocytic lymphoma.

Authors:  H L Evans; J J Butler; E L Youness
Journal:  Cancer       Date:  1978-04       Impact factor: 6.860

9.  Malignant lymphoma, intermediate lymphocytic type: a clinicopathologic study of 42 cases.

Authors:  D D Weisenburger; B N Nathwani; L W Diamond; C D Winberg; H Rappaport
Journal:  Cancer       Date:  1981-09-15       Impact factor: 6.860

10.  Prognostic factors in non-Hodgkin's lymphoma: the importance of symptomatic stage as an adjunct to the Kiel histopathological classification.

Authors:  R C Leonard; J Cuzick; I C MacLennan; R I Vanhegan; P H Mackie; C V McCormick
Journal:  Br J Cancer       Date:  1983-01       Impact factor: 7.640
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  9 in total

Review 1.  Proliferation markers in tumours: interpretation and clinical value.

Authors:  P J van Diest; G Brugal; J P Baak
Journal:  J Clin Pathol       Date:  1998-10       Impact factor: 3.411

2.  Automatic detection of follicular regions in H&E images using iterative shape index.

Authors:  K Belkacem-Boussaid; S Samsi; G Lozanski; M N Gurcan
Journal:  Comput Med Imaging Graph       Date:  2011-04-20       Impact factor: 4.790

3.  DNA flow cytometry of follicular non-Hodgkin's lymphoma.

Authors:  J C Macartney; R S Camplejohn; R Morris; K Hollowood; D Clarke; A Timothy
Journal:  J Clin Pathol       Date:  1991-03       Impact factor: 3.411

Review 4.  Review: assessment of cell proliferation in histological material.

Authors:  P A Hall; D A Levison
Journal:  J Clin Pathol       Date:  1990-03       Impact factor: 3.411

5.  Computer-aided classification of centroblast cells in follicular lymphoma.

Authors:  Kamel Belkacem-Boussaid; Michael Pennell; Gerard Lozanski; Arwa Shana'ah; Metin Gurcan
Journal:  Anal Quant Cytol Histol       Date:  2010-10       Impact factor: 0.302

6.  Extraction of color features in the spectral domain to recognize centroblasts in histopathology.

Authors:  Kamel Belkacem-Boussaid; Olcay Sertel; Gerard Lozanski; Arwa Shana'aah; Metin Gurcan
Journal:  Conf Proc IEEE Eng Med Biol Soc       Date:  2009

Review 7.  Prognostic factors in the non-Hodgkin's lymphomas--a time for consensus?

Authors:  J A Child
Journal:  Br J Cancer       Date:  1991-06       Impact factor: 7.640

8.  Cell kinetics: an independent prognostic variable in stage II melanoma of the skin.

Authors:  A Costa; R Silvestrini; G Mezzanotte; M Vaglini; E Grignolio; C Clemente; N Cascinelli
Journal:  Br J Cancer       Date:  1990-11       Impact factor: 7.640

9.  Contribution of 3H-thymidine labelling index and flow cytometric S-phase in predicting survival of patients with non-Hodgkin's lymphoma.

Authors:  A Costa; R Silvestrini; R Giardini; G Messina-Gabrielli; P Boracchi; S Veneroni
Journal:  Br J Cancer       Date:  1992-10       Impact factor: 7.640
  9 in total

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