| Literature DB >> 31707701 |
Weilin Zhang1,2, Juan Xie1,2, Luhua Lai3,4.
Abstract
Correlation between an allosteric site and its orthosteric site refers to the phenomenon that perturbations like ligand binding, mutation, or posttranslational modifications at the allosteric site leverage variation in the orthosteric site. Understanding this kind of correlation not only helps to disclose how information is transmitted in allosteric regulation but also provides clues for allosteric drug discovery. This chapter starts with an overview of correlation studies on allosteric and orthosteric sites and then introduces recent progress in evolutionary and simulation-based dynamic studies. Discussions and perspectives on future directions are also given.Keywords: Community analysis; Correlation; Elastic network model; Evolutionary analysis; Molecular dynamics; Mutual information; Rigid-body simulation; Statistical coupling analysis; Two state Go̅ model
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Year: 2019 PMID： 31707701 DOI： 10.1007/978-981-13-8719-7_5
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622