| Literature DB >> 31707678 |
Robert D Schwab1, Darel Martínez Bedoya1, Tiffany R King1, Bruce L Levine1,2, Avery D Posey3,4,5.
Abstract
Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of activation and transduction, and culture supplementation.Entities:
Keywords: CAR-T cells; T cell manufacturing
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Year: 2020 PMID： 31707678 DOI： 10.1007/978-1-0716-0146-4_15
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745