Literature DB >> 31707611

Involvement of p38 MAPK pathway in benzo(a)pyrene-induced human hepatoma cell migration and invasion.

Yadong Wang1, Li Shi2, Jiangmin Li3, Li Li3, Haiyu Wang3, Haiyan Yang4.   

Abstract

The objective of this study was to investigate the potential role of p38 mitogen-activated protein kinases (MAPK) in benzo(a)pyrene (BaP)-induced hepatoma cell migration and invasion. Western blot assay was applied to detect the expression of proteins. qRT-PCR assay was used to measure the expression of mRNA. Wound healing assay and Transwell invasion assay were performed to evaluate cell migratory ability and cell invasive ability, respectively. Our data showed that BaP exposure increased the expression of p-p38 protein in human hepatoma HepG2 cells. Exposure to BaP facilitated HepG2 cell migration and invasion, which could be blocked by p38 MAPK inhibitors. In addition, BaP exposure induced upregulation of MMP9 mRNA expression, which was modulated by p-p38. In conclusion, p38 MAPK pathway was involved in BaP-induced hepatoma cell migration and invasion.

Entities:  

Keywords:  Benzo(a)pyrene; HepG2 cells; Invasion; MMP9; Migration; p38 MAPK

Year:  2019        PMID： 31707611     DOI： 10.1007/s11356-019-06733-3

Source DB:  PubMed          Journal:  Environ Sci Pollut Res Int        ISSN： 0944-1344            Impact factor:   4.223


  54 in total

Review 1.  Mapping out p38MAPK.

Authors:  Elizabeth A Bonney
Journal:  Am J Reprod Immunol       Date:  2017-02-13       Impact factor: 3.886

Review 2.  Mechanisms and functions of p38 MAPK signalling.

Authors:  Ana Cuadrado; Angel R Nebreda
Journal:  Biochem J       Date:  2010-08-01       Impact factor: 3.857

Review 3.  p38 MAPK: a dual role in hepatocyte proliferation through reactive oxygen species.

Authors:  A M Tormos; R Taléns-Visconti; A R Nebreda; J Sastre
Journal:  Free Radic Res       Date:  2013-10-04

4.  Oxidative stress and cell-cycle change induced by coexposed PCB126 and benzo(a) pyrene to human hepatoma (HepG2) cells.

Authors:  Wei Wei; Xiao-Feng Li; Xiao-Nuan Li; Xue-Min Chen; Ai-Lin Liu; Wen-Qing Lu
Journal:  Environ Toxicol       Date:  2010-12-08       Impact factor: 4.119

5.  Benzo(a)pyrene in gasoline partially persists in automobile exhaust.

Authors:  C R Begeman; J M Colucci
Journal:  Science       Date:  1968-07-19       Impact factor: 47.728

6.  MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.

Authors:  April K Marrone; Volodymyr Tryndyak; Frederick A Beland; Igor P Pogribny
Journal:  Toxicol Sci       Date:  2015-11-24       Impact factor: 4.849

7.  IL-17A promotes the migration and invasiveness of cervical cancer cells by coordinately activating MMPs expression via the p38/NF-κB signal pathway.

Authors:  Minjuan Feng; Yidong Wang; Kunlun Chen; Zhuoqiong Bian; Qing Gao
Journal:  PLoS One       Date:  2014-09-24       Impact factor: 3.240

8.  Benzo(a)pyrene promotes Hep-G2 cell migration and invasion by upregulating phosphorylated extracellular signal-regulated kinase expression.

Authors:  Yadong Wang; Teng Pan; Li Li; Haiyu Wang; Ding Zhang; Haiyan Yang
Journal:  Oncol Lett       Date:  2018-03-29       Impact factor: 2.967

9.  IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9.

Authors:  Qiaojia Huang; Fenghua Lan; Xiaoting Wang; Yinghao Yu; Xuenong Ouyang; Feng Zheng; Junyong Han; Youdong Lin; Yanchuan Xie; Feilai Xie; Wei Liu; Xiaoli Yang; Han Wang; Lihong Dong; Lie Wang; Jianming Tan
Journal:  Mol Cancer       Date:  2014-01-31       Impact factor: 27.401

10.  Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP‑2/9 production via the p38 MAPK signaling pathway.

Authors:  Gong Cheng; Fengguang Gao; Xiujiang Sun; Haiyong Bi; Yonglin Zhu
Journal:  Mol Med Rep       Date:  2016-08-22       Impact factor: 2.952
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