Mansueto Gomes-Neto1,2,3,4, André Rodrigues Durães5, Lino Sergio Rocha Conceição6,7, Leonardo Roever8, Tong Liu9,10, Gary Tse11, Giuseppe Biondi-Zoccai12, Ana Lucia Barbosa Goes13,14, Iura Gonzalez Nogueira Alves14, Øyvind Ellingsen15,16, Vitor Oliveira Carvalho6,7. 1. Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil. mansueto.neto@ufba.br. 2. Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil. mansueto.neto@ufba.br. 3. Physiotherapy Research Group, UFBA, Salvador, Brazil. mansueto.neto@ufba.br. 4. The GREAT Group (GRupo de Estudos em ATividade física), São Paulo, Brazil. mansueto.neto@ufba.br. 5. Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil. 6. The GREAT Group (GRupo de Estudos em ATividade física), São Paulo, Brazil. 7. Physical Therapy Department, Federal University of Sergipe - UFS, Aracaju, SE, Brazil. 8. Department of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil. 9. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China. 10. Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. 11. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy. 12. Mediterranea Cardiocentro, Naples, Italy. 13. Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil. 14. Physiotherapy Research Group, UFBA, Salvador, Brazil. 15. K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. 16. Department of Cardiology, Trondheim University Hospital, St. Olavs Hospital, Trondheim, Norway.
Abstract
PURPOSE OF REVIEW: The aim of this study was to determine the effects of aerobic exercise on peak oxygen uptake (peak VO2), minute ventilation/carbon dioxide production (VE/VCO2 slope), and health-related quality of life (HRQoL) among patients with heart failure (HF) and preserved ejection fraction (HFpEF). RECENT FINDINGS: We conducted a Cochrane Library, MEDLINE/PubMed, Physiotherapy Evidence Database, and SciELO search (from 1985 to May 2019) for randomized controlled trials that evaluated the effects of aerobic exercise in HFpEF patients. We calculated the mean differences (MD) and 95% confidence interval (CI). Ten intervention studies were included providing a total of 399 patients. Compared with control, aerobic exercise resulted in improvement in peak VO2 MD 1.9 mL kg-1 min-1 (95% CI 1.3 to 2.5; N = 314) and HRQoL measured by Minnesota Living with Heart Failure MD 5.4 (95% CI - 10.5 to - 0.2; N = 256). No significant difference in VE/VCO2 slope was found between participants in the aerobic exercise group and the control group. The quality of evidence for peak VO2 and HRQoL was assessed as being moderate. Aerobic exercise moderately improves peak VO2 and HRQoL and should be considered a strategy of rehabilitation of HFpEF individuals.
PURPOSE OF REVIEW: The aim of this study was to determine the effects of aerobic exercise on peak oxygen uptake (peak VO2), minute ventilation/carbon dioxide production (VE/VCO2 slope), and health-related quality of life (HRQoL) among patients with heart failure (HF) and preserved ejection fraction (HFpEF). RECENT FINDINGS: We conducted a Cochrane Library, MEDLINE/PubMed, Physiotherapy Evidence Database, and SciELO search (from 1985 to May 2019) for randomized controlled trials that evaluated the effects of aerobic exercise in HFpEF patients. We calculated the mean differences (MD) and 95% confidence interval (CI). Ten intervention studies were included providing a total of 399 patients. Compared with control, aerobic exercise resulted in improvement in peak VO2 MD 1.9 mL kg-1 min-1 (95% CI 1.3 to 2.5; N = 314) and HRQoL measured by Minnesota Living with Heart Failure MD 5.4 (95% CI - 10.5 to - 0.2; N = 256). No significant difference in VE/VCO2 slope was found between participants in the aerobic exercise group and the control group. The quality of evidence for peak VO2 and HRQoL was assessed as being moderate. Aerobic exercise moderately improves peak VO2 and HRQoL and should be considered a strategy of rehabilitation of HFpEF individuals.
Entities:
Keywords:
Aerobic exercise; Heart failure; Left ventricular ejection fraction
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