Burcu Yuksel1, Pinar Koc2, Eylem Ozaydin Goksu3, Ertan Karacay4, Fatma Kurtulus5, Yesim Cekin6, Yasemin Bicer Gomceli7. 1. Antalya Training and Research Hospital, Neurology Department, Muratpasa, 07050 Antalya, Turkey. Electronic address: dr.burcuy@hotmail.com. 2. Antalya Training and Research Hospital, Radiology Department, Muratpasa, 07050 Antalya, Turkey. 3. Antalya Training and Research Hospital, Neurology Department, Muratpasa, 07050 Antalya, Turkey. Electronic address: eylemozaydin@hotmail.com. 4. Antalya Training and Research Hospital, Neurology Department, Muratpasa, 07050 Antalya, Turkey. Electronic address: ertan.karacay1@hotmail.com. 5. Antalya Training and Research Hospital, Neurology Department, Muratpasa, 07050 Antalya, Turkey. Electronic address: fatma72kurtulus@yahoo.com. 6. Antalya Training and Research Hospital, Microbiology Department, Muratpasa, 07050 Antalya, Turkey. Electronic address: yesimcekin@hotmail.com. 7. Antalya Training and Research Hospital, Neurology Department, Muratpasa, 07050 Antalya, Turkey. Electronic address: yasemingomceli@hotmail.com.
Abstract
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We aimed to discuss possible predisposing factors to atherosclerosis such as carotid intima-media thickness (CIMT) and high-sensitivity C-reactive protein (Hs-CRP) levels in MS. METHODS: Thirty-five ambulatory patients with relapsing-remitting MS (RRMS) (22 females and 13 males) and 34 healthy controls (21 females and 13 males) with similar demographic variables were included. Blood cell counts, cholesterol levels, vitamin D and B12, Hs-CRP levels, body mass index (BMI), history of smoking, and CIMT of both groups, Expanded Disability Status Scale (EDSS) scores, and disease duration of patients were recorded. Patients with a history of other vascular diseases such as hypertension, diabetes mellitus, peripheral artery disease, and acute relapses were excluded. RESULTS: Sixty-nine participants were included. The mean age of the study population was 35.8±7.1 years. Right CIMT was significantly greater in the patient population (P<0.001). Spearman's correlation coefficient between age and right CIMT was r=0.41, P=0.01. When we compared the Hs-CRP with a cut-off value of ≤3, the right, left, and mean CIMT levels were not statistically significant (P=0.17; P=0.22; P=0.15). The mean serum vitamin D levels were higher in the patient group and this was statistically significant (P<0.001). The statistically significant factors identified with univariate analysis with P<0.2 were further entered into multivariate modelling. CONCLUSION: CIMT seems to be affected in patients with MS by means of the disease itself and age. Thus, CIMT might reflect the predisposition to subclinical atherosclerosis more than Hs-CRP. Further investigation in a large MS population is still needed.
BACKGROUND:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We aimed to discuss possible predisposing factors to atherosclerosis such as carotid intima-media thickness (CIMT) and high-sensitivity C-reactive protein (Hs-CRP) levels in MS. METHODS: Thirty-five ambulatory patients with relapsing-remitting MS (RRMS) (22 females and 13 males) and 34 healthy controls (21 females and 13 males) with similar demographic variables were included. Blood cell counts, cholesterol levels, vitamin D and B12, Hs-CRP levels, body mass index (BMI), history of smoking, and CIMT of both groups, Expanded Disability Status Scale (EDSS) scores, and disease duration of patients were recorded. Patients with a history of other vascular diseases such as hypertension, diabetes mellitus, peripheral artery disease, and acute relapses were excluded. RESULTS: Sixty-nine participants were included. The mean age of the study population was 35.8±7.1 years. Right CIMT was significantly greater in the patient population (P<0.001). Spearman's correlation coefficient between age and right CIMT was r=0.41, P=0.01. When we compared the Hs-CRP with a cut-off value of ≤3, the right, left, and mean CIMT levels were not statistically significant (P=0.17; P=0.22; P=0.15). The mean serum vitamin D levels were higher in the patient group and this was statistically significant (P<0.001). The statistically significant factors identified with univariate analysis with P<0.2 were further entered into multivariate modelling. CONCLUSION:CIMT seems to be affected in patients with MS by means of the disease itself and age. Thus, CIMT might reflect the predisposition to subclinical atherosclerosis more than Hs-CRP. Further investigation in a large MS population is still needed.
Authors: Marjan Rahimi Farzan; Sara Esmaeili; Zahra Mirzaasgari; Negin Mahmoudi Hamidabad; Seyedeh Niloufar Rafiei Alavi; Mohammad Taghi Joghataei; Mohammad Reza Motamed Journal: Ann Med Surg (Lond) Date: 2022-02-09