Alireza Ghardashi-Afousi1, Mohsen Davoodi2, Behnam Keshtkar- Hesamabadi3, Maryam Asvadi-Fard4, Mohammad Ali Babaee Bigi5, Mohammad Reza Izadi6, Abbas Ali Gaeini7. 1. Department of Exercise Physiology, Faculty of Physical Education and Exercise Sciences, University of Tehran, Tehran, IR, Iran. Electronic address: Ghardashi.a@ut.ac.ir. 2. Shiraz University of Medical Science, Shiraz, IR, Iran. 3. Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, IR, Iran. 4. Department of Medicine, Iran University of Medical Science, Tehran, IR, Iran. 5. Cardiovascular Research Center, Shiraz University of Medical Science, Shiraz, IR, Iran. 6. Department of Exercise Physiology, Faculty of Physical Education and Exercise Sciences, University of Shahid Chamran, Ahvaz, IR, Iran. 7. Department of Exercise Physiology, Faculty of Physical Education and Exercise Sciences, University of Tehran, Tehran, IR, Iran. Electronic address: Aagaeini@ut.ac.ir.
Abstract
AIMS: Carotid intima-media thickness (cIMT) is a validated surrogate marker of atherosclerosis. Dickkopf-1 (Dkk-1) and sclerostin modulate wingless signaling, which is involved in atherosclerosis. The purpose of this study was to investigate whether 12 weeks of high-intensity interval training (HIIT) would improve cIMT and serum Dkk-1 and sclerostin levels in patients with type 2 diabetes. METHODS:Seventy-four sedentary patients with type 2 diabetes were randomly divided into HIIT and control groups. The HIIT group intervention was 6 intervals (4 min) at 85%-90% HRmax separated by 3 min at 45%-50% HRmax in 3 sessions/week for 12 weeks. Before and after the intervention, cIMT, artery diameter and wall/lm ratio were recorded with high-resolution ultrasound. Serum sclerostin and Dkk-1 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS:cIMT decreased significantly in the HIIT group (0.83 ± 0.17 baseline, 0.71 ± 0.14 follow-up) compared to the control group (0.84 ± 0.20 baseline, 0.85 ± 0.19 follow-up) (P < .05). Dkk-1 and sclerostin decreased significantly after 12 weeks of HIIT (P < .01). In addition, VO2peak was increased in the HIIT group than the control group (by 6.2 mL/kg/min) (P < .05). There was a positive correlation between percent changes in cIMT and percent changes in Dkk-1 and sclerostin (both P < .01). Additionally, there were a negative correlation between percent changes VO2peak and cIMT (r = - 0.740, P = .003), Dkk-1 (r = - 0.844, P < .001) and sclerostin (r = - 0.575, P = .001) in HIIT group. CONCLUSION: Our results indicate that HIIT decreases cIMT, serum levels of Dkk-1 and sclerostin and improves VO2peak in patients with type 2 diabetes.
RCT Entities:
AIMS: Carotid intima-media thickness (cIMT) is a validated surrogate marker of atherosclerosis. Dickkopf-1 (Dkk-1) and sclerostin modulate wingless signaling, which is involved in atherosclerosis. The purpose of this study was to investigate whether 12 weeks of high-intensity interval training (HIIT) would improve cIMT and serum Dkk-1 and sclerostin levels in patients with type 2 diabetes. METHODS: Seventy-four sedentary patients with type 2 diabetes were randomly divided into HIIT and control groups. The HIIT group intervention was 6 intervals (4 min) at 85%-90% HRmax separated by 3 min at 45%-50% HRmax in 3 sessions/week for 12 weeks. Before and after the intervention, cIMT, artery diameter and wall/lm ratio were recorded with high-resolution ultrasound. Serum sclerostin and Dkk-1 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: cIMT decreased significantly in the HIIT group (0.83 ± 0.17 baseline, 0.71 ± 0.14 follow-up) compared to the control group (0.84 ± 0.20 baseline, 0.85 ± 0.19 follow-up) (P < .05). Dkk-1 and sclerostin decreased significantly after 12 weeks of HIIT (P < .01). In addition, VO2peak was increased in the HIIT group than the control group (by 6.2 mL/kg/min) (P < .05). There was a positive correlation between percent changes in cIMT and percent changes in Dkk-1 and sclerostin (both P < .01). Additionally, there were a negative correlation between percent changes VO2peak and cIMT (r = - 0.740, P = .003), Dkk-1 (r = - 0.844, P < .001) and sclerostin (r = - 0.575, P = .001) in HIIT group. CONCLUSION: Our results indicate that HIIT decreases cIMT, serum levels of Dkk-1 and sclerostin and improves VO2peak in patients with type 2 diabetes.
Authors: Marietta Herrmann; Klaus Engelke; Regina Ebert; Sigrid Müller-Deubert; Maximilian Rudert; Fani Ziouti; Franziska Jundt; Dieter Felsenberg; Franz Jakob Journal: Biomolecules Date: 2020-03-10
Authors: Adam Kern; Tomasz Stompór; Jolanta Kiewisz; Bartłomiej E Kraziński; Jacek Kiezun; Marta Kiezun; Jerzy Górny; Ewa Sienkiewicz; Leszek Gromadziński; Dariusz Onichimowski; Jacek Bil Journal: J Pers Med Date: 2021-03-06