Shi-Ping Luo1, Qi-Sen Wu2, Hong Chen1, Xiao-Xiao Wang3, Qing-Xia Chen4, Jie Zhang1, Chuan-Gui Song5. 1. Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China. 2. Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, China. 3. Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Department of Gynecology and Obstetrics, Fujian Provincial Maternity and Children Health Hospital, Fujian Medical University, Fuzhou, China. 4. Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Department of Burn and Plastic Surgery, Affiliated Longyan First Hospital, Fujian Medical University, Longyan, China. 5. Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China. Electronic address: songchuangui@yahoo.com.
Abstract
BACKGROUND: The eighth edition of the American Cancer Joint Committee on Cancer (AJCC) staging system for breast cancer put forward the prognostic stage groups for the first time based on the traditional anatomic tumor-node-metastasis staging system. Our study intends to validate the predictive significance of the eighth edition staging system in triple-negative breast cancer (TNBC) patients. MATERIALS AND METHODS: We collected and accessed 26,589 eligible cases of TNBC from the Surveillance, Epidemiology, and End Results database (2010-2015) and reclassified the patient cohort according to the eighth edition of the AJCC staging system into anatomic and prognostic stages. RESULTS: The results showed that more than half of the patients upstaged in the prognostic stage when compared with the anatomic stage. By comparing with the anatomic stage, the prognostic stage had a higher likelihood ratio and linear trend χ2 values. The prognostic stage group also had higher Akaike information criterion and Bayesian information criterion values than the anatomic stage group. CONCLUSIONS: The prognostic staging system in TNBC patients performs more optimistic prognostic stratification and predictability than the anatomic staging system. Moreover, the latest AJCC staging system has a milestone importance to the history of breast cancer staging system.
BACKGROUND: The eighth edition of the American Cancer Joint Committee on Cancer (AJCC) staging system for breast cancer put forward the prognostic stage groups for the first time based on the traditional anatomic tumor-node-metastasis staging system. Our study intends to validate the predictive significance of the eighth edition staging system in triple-negative breast cancer (TNBC) patients. MATERIALS AND METHODS: We collected and accessed 26,589 eligible cases of TNBC from the Surveillance, Epidemiology, and End Results database (2010-2015) and reclassified the patient cohort according to the eighth edition of the AJCC staging system into anatomic and prognostic stages. RESULTS: The results showed that more than half of the patients upstaged in the prognostic stage when compared with the anatomic stage. By comparing with the anatomic stage, the prognostic stage had a higher likelihood ratio and linear trend χ2 values. The prognostic stage group also had higher Akaike information criterion and Bayesian information criterion values than the anatomic stage group. CONCLUSIONS: The prognostic staging system in TNBC patients performs more optimistic prognostic stratification and predictability than the anatomic staging system. Moreover, the latest AJCC staging system has a milestone importance to the history of breast cancer staging system.
Authors: Jiehua He; Julia Y Tsang; Xiaodan Xu; Jibin Li; Mei Li; Xue Chao; Yuanyuan Xu; Rongzhen Luo; Gary M Tse; Peng Sun Journal: BMC Cancer Date: 2020-01-06 Impact factor: 4.430