Literature DB >> 31706505

Impaired Muscle Regeneration in Cancer-Associated Cachexia.

Paige C Arneson1, Jason D Doles2.   

Abstract

Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cachexia; muscle wasting; regeneration; satellite cells

Year:  2019        PMID： 31706505     DOI： 10.1016/j.trecan.2019.07.010

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  4 in total

1.  Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia.

Authors:  Surendra K Shukla; Spas D Markov; Kuldeep S Attri; Enza Vernucci; Ryan J King; Aneesha Dasgupta; Paul M Grandgenett; Michael A Hollingsworth; Pankaj K Singh; Fang Yu; Kamiya Mehla
Journal:  Cancer Lett       Date:  2020-04-25       Impact factor: 8.679

Review 2.  Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions.

Authors:  Jawed A Siddiqui; Ramesh Pothuraju; Maneesh Jain; Surinder K Batra; Mohd W Nasser
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2020-03-25       Impact factor: 10.680

3.  Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.

Authors:  Maria Borja-Gonzalez; Jose C Casas-Martinez; Brian McDonagh; Katarzyna Goljanek-Whysall
Journal:  Antioxidants (Basel)       Date:  2020-04-23

4.  Human pancreatic tumour organoid-derived factors enhance myogenic differentiation.

Authors:  Rianne D W Vaes; David P J van Dijk; Elham Aïda Farshadi; Steven W M Olde Damink; Sander S Rensen; Ramon C Langen
Journal:  J Cachexia Sarcopenia Muscle       Date:  2022-02-11       Impact factor: 12.910
  4 in total

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