Literature DB >> 31706504

Phages Enter the Fight against Colorectal Cancer.

Vinicius Kannen1, Lee Parry2, Francis L Martin3.   

Abstract

Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  bacteriophage; chemotherapy; colorectal cancer; microbiota

Year:  2019        PMID： 31706504     DOI： 10.1016/j.trecan.2019.08.002

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  5 in total

1.  Alterations, Interactions, and Diagnostic Potential of Gut Bacteria and Viruses in Colorectal Cancer.

Authors:  Renyuan Gao; Yefei Zhu; Cheng Kong; Kai Xia; Hao Li; Yin Zhu; Xiaohui Zhang; Yongqiang Liu; Hui Zhong; Rong Yang; Chunqiu Chen; Nan Qin; Huanlong Qin
Journal:  Front Cell Infect Microbiol       Date:  2021-07-06       Impact factor: 5.293

Review 2.  Influence of Iron on the Gut Microbiota in Colorectal Cancer.

Authors:  Oliver Phipps; Hafid O Al-Hassi; Mohammed N Quraishi; Aditi Kumar; Matthew J Brookes
Journal:  Nutrients       Date:  2020-08-20       Impact factor: 5.717

3.  Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

Authors:  Chun-Chao Chang; Wei-Yu Kao; Chih-Yi Liu; Hui-Hsien Su; Yu-An Kan; Pao-Ying Lin; Wei-Chi Ku; Kang-Wei Chang; Ruey-Neng Yang; Chi-Jung Huang
Journal:  Int J Oncol       Date:  2022-04-13       Impact factor: 5.884

Review 4.  Pulmonary Delivery of Emerging Antibacterials for Bacterial Lung Infections Treatment.

Authors:  Jiaqi Li; Huangliang Zheng; Sharon Shui Yee Leung
Journal:  Pharm Res       Date:  2022-09-19       Impact factor: 4.580

Review 5.  Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer.

Authors:  Chenchen Bi; Geqiong Xiao; Chunyan Liu; Junwei Yan; Jiaqi Chen; Wenzhang Si; Jian Zhang; Zheng Liu
Journal:  Front Cell Dev Biol       Date:  2021-12-08
  5 in total

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