S W M C Maass1, L M Boerman2, P F M Verhaak3, J Du4, G H de Bock5, A J Berendsen6. 1. University of Groningen, University Medical Center Groningen, Department of General Practice and Elderly Care Medicine, PO Box 196, 9700 AD, Groningen, the Netherlands. Electronic address: s.w.m.c.maass@umcg.nl. 2. University of Groningen, University Medical Center Groningen, Department of General Practice and Elderly Care Medicine, PO Box 196, 9700 AD, Groningen, the Netherlands. Electronic address: l.m.boerman01@umcg.nl. 3. University of Groningen, University Medical Center Groningen, Department of General Practice and Elderly Care Medicine, PO Box 196, 9700 AD, Groningen, the Netherlands; NIVEL, Netherlands Institute of Health Services Research, Utrecht, the Netherlands. Electronic address: p.verhaak@nivel.nl. 4. University of Groningen, University Medical Center Groningen, Department of Epidemiology, PO Box 30001, 9700 RB, Groningen, the Netherlands. Electronic address: j.du@umcg.nl. 5. University of Groningen, University Medical Center Groningen, Department of Epidemiology, PO Box 30001, 9700 RB, Groningen, the Netherlands. Electronic address: g.h.de.bock@umcg.nl. 6. University of Groningen, University Medical Center Groningen, Department of General Practice and Elderly Care Medicine, PO Box 196, 9700 AD, Groningen, the Netherlands. Electronic address: a.j.berendsen@umcg.nl.
Abstract
INTRODUCTION: Breast cancer survivors often experience psychological distress shortly after diagnosis. Long-term psychological effects, however, have not been clearly demonstrated. METHODS: This cross-sectional cohort study included 350 breast cancer survivors and 350 age-matched and general-practitioner-matched women. The median follow-up was 10 years. Using logistic regression we compared breast cancer survivors with controls on having (severe) symptoms of depression and/or anxiety, as measured with the Hospital Anxiety and Depression Scale. In multivariable logistic regression, we adjusted the results for a history of depression or prescription of antidepressants. RESULTS: Larger proportions of breast cancer survivors experienced symptoms of depression (10.6%) compared with controls (4.9%) and symptoms of anxiety (18.6%) compared with controls (16.3%). The odds of symptoms of depression (OR 2.3, 95%CI 1.3-4.2), severe symptoms of depression (OR 3.3, 95%CI 1.1-10.3) and severe symptoms of anxiety (OR 2.1, 95%CI, 1.1-4.0) were significantly higher for breast cancer survivors than for controls, even after adjusting for history of depression or prescription of antidepressants. No significant difference was seen for mild symptoms of anxiety. CONCLUSIONS: Breast cancer survivors have an increased risk of symptoms of depression, including severe symptoms, and severe symptoms of anxiety compared with controls, for up to at least 10 years after diagnosis.
INTRODUCTION:Breast cancer survivors often experience psychological distress shortly after diagnosis. Long-term psychological effects, however, have not been clearly demonstrated. METHODS: This cross-sectional cohort study included 350 breast cancer survivors and 350 age-matched and general-practitioner-matched women. The median follow-up was 10 years. Using logistic regression we compared breast cancer survivors with controls on having (severe) symptoms of depression and/or anxiety, as measured with the Hospital Anxiety and Depression Scale. In multivariable logistic regression, we adjusted the results for a history of depression or prescription of antidepressants. RESULTS: Larger proportions of breast cancer survivors experienced symptoms of depression (10.6%) compared with controls (4.9%) and symptoms of anxiety (18.6%) compared with controls (16.3%). The odds of symptoms of depression (OR 2.3, 95%CI 1.3-4.2), severe symptoms of depression (OR 3.3, 95%CI 1.1-10.3) and severe symptoms of anxiety (OR 2.1, 95%CI, 1.1-4.0) were significantly higher for breast cancer survivors than for controls, even after adjusting for history of depression or prescription of antidepressants. No significant difference was seen for mild symptoms of anxiety. CONCLUSIONS:Breast cancer survivors have an increased risk of symptoms of depression, including severe symptoms, and severe symptoms of anxiety compared with controls, for up to at least 10 years after diagnosis.
Authors: Tanmayi Pai; Lauren Cornell; Danushka Seneviratne; Shehzad Niazi; Dawn Mussallem; Laura Vallow Journal: Breast Cancer Res Treat Date: 2021-04-12 Impact factor: 4.872
Authors: Julienne E Bower; Ann H Partridge; Antonio C Wolff; Elissa D Thorner; Michael R Irwin; Hadine Joffe; Laura Petersen; Catherine M Crespi; Patricia A Ganz Journal: J Clin Oncol Date: 2021-08-18 Impact factor: 44.544
Authors: S W M C Maass; L M Boerman; D Brandenbarg; P F M Verhaak; J H Maduro; G H de Bock; A J Berendsen Journal: Breast Date: 2020-09-30 Impact factor: 4.380
Authors: Diane Von Ah; Adele D Crouch; Patrick O Monahan; Timothy E Stump; Frederick W Unverzagt; Susan Storey; Andrea A Cohee; David Cella; Victoria L Champion Journal: J Cancer Surviv Date: 2021-06-26 Impact factor: 4.062