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Literature DB >> 31704772

T. gondii inveSTING in a latent future.

Abstract

Toxoplasma gondii is an obligate protozoan parasite that naturally infects all mammals, where it alters the host environment to establish chronic infection. Wang and colleagues uncover a new role for the T. gondii protein GRA15 in inducing an anti-parasite response via the interferon stimulator STING. This parasite-driven host defense limits Toxoplasma replication while maintaining host survival, creating an ideal niche for the establishment of latency.

Entities: Disease Species

Mesh：

Substances：

Year: 2019 PMID： 31704772 PMCID： PMC6851304 DOI： 10.1074/jbc.H119.011296

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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References

7 in total

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Authors: Felix Yarovinsky; Dekai Zhang; John F Andersen; Gerard L Bannenberg; Charles N Serhan; Matthew S Hayden; Sara Hieny; Fayyaz S Sutterwala; Richard A Flavell; Sankar Ghosh; Alan Sher
Journal: Science Date: 2005-04-28 Impact factor: 47.728

2. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.

Authors: Peiyan Wang; Siji Li; Yingchi Zhao; Baohuan Zhang; Yunfei Li; Shengde Liu; Hongqiang Du; Lili Cao; Meiling Ou; Xiaohong Ye; Peng Li; Xiang Gao; Penghua Wang; Chunxia Jing; Feng Shao; Guang Yang; Fuping You
Journal: J Biol Chem Date: 2019-08-15 Impact factor: 5.157

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Authors: A Alicia Koblansky; Dragana Jankovic; Hyunju Oh; Sara Hieny; Waradon Sungnak; Ramkumar Mathur; Matthew S Hayden; Shizuo Akira; Alan Sher; Sankar Ghosh
Journal: Immunity Date: 2012-12-13 Impact factor: 31.745

4. Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA.

Authors: Emily E Rosowski; Quynh P Nguyen; Ana Camejo; Eric Spooner; Jeroen P J Saeij
Journal: Infect Immun Date: 2013-11-25 Impact factor: 3.441

T. gondii inveSTING in a latent future.

1. TLR11 activation of dendritic cells by a protozoan profilin-like protein.

2. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.

3. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

4. Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA.

5. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.

6. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.

7. Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation.