Linfang Zhang1, Zhiheng Chen2, Xiujuan Xia1, Jingshu Chi3, Huan Li3, Xiaoming Liu3, Rong Li3, Yixi Li4, Da Liu4, Delin Tian3, Hui Wang3, Greg F Petroski5, Greg C Flaker4, Hong Hao4, Zhenguo Liu6, Canxia Xu7. 1. Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA. 2. Department of Health Management, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China. 3. Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China. 4. Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA. 5. Biostatistics and Research Design Unit, University of Missouri School of Medicine, Columbia, MO, USA. 6. Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA. Electronic address: liuzheng@health.missouri.edu. 7. Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China. Electronic address: xucanxia2000@163.com.
Abstract
BACKGROUND AND AIMS: Atherosclerosis is an important contributing factor to cardiovascular mortality. The role of Helicobacter pylori (H. pylori) infection in atherosclerosis is inconsistent and sometimes controversial. The present study aimed to determine if H. pylori infection is associated with carotid atherosclerosis. METHODS: 17,613 males and females with both carotid ultrasonic examination and 13C-urea breath test for H. pylori infection were screened by a major Chinese university hospital from March 2012 to March 2017 for the study. Baseline demographics, cardiac risk factors, and laboratory studies were obtained. After exclusion for pre-specified conditions, 12,836 individuals were included in the analysis, including 8157 men (63.5%) and 4679 women (36.5%). Analysis was also made for 5-year follow-up data of 1216 subjects (869 males and 347 females) with and without H. pylori infection for development and progression of carotid atherosclerosis. RESULTS: After adjusting for age, sex, body mass index, lipid profile, hypertension, renal function, diabetes mellitus, and smoking, H. pylori infection was found as an independent risk factor for carotid atherosclerosis in males under 50 years, but not in older males or females (odds ratio 1.229, 95% CI 1.054-1.434, p = 0.009). Follow-up data analysis showed that the incidence of carotid atherosclerosis from no atherosclerosis to detectable lesions was significantly higher in young males with persistent H. pylori infection than those without H. pylori infection (p = 0.028) after 3 years. CONCLUSIONS: These data suggest that H. pylori infection might be an important risk factor for carotid atherosclerosis in young Chinese males under 50.
BACKGROUND AND AIMS: Atherosclerosis is an important contributing factor to cardiovascular mortality. The role of Helicobacter pylori (H. pylori) infection in atherosclerosis is inconsistent and sometimes controversial. The present study aimed to determine if H. pylori infection is associated with carotid atherosclerosis. METHODS: 17,613 males and females with both carotid ultrasonic examination and 13C-urea breath test for H. pylori infection were screened by a major Chinese university hospital from March 2012 to March 2017 for the study. Baseline demographics, cardiac risk factors, and laboratory studies were obtained. After exclusion for pre-specified conditions, 12,836 individuals were included in the analysis, including 8157 men (63.5%) and 4679 women (36.5%). Analysis was also made for 5-year follow-up data of 1216 subjects (869 males and 347 females) with and without H. pylori infection for development and progression of carotid atherosclerosis. RESULTS: After adjusting for age, sex, body mass index, lipid profile, hypertension, renal function, diabetes mellitus, and smoking, H. pylori infection was found as an independent risk factor for carotid atherosclerosis in males under 50 years, but not in older males or females (odds ratio 1.229, 95% CI 1.054-1.434, p = 0.009). Follow-up data analysis showed that the incidence of carotid atherosclerosis from no atherosclerosis to detectable lesions was significantly higher in young males with persistent H. pylori infection than those without H. pylori infection (p = 0.028) after 3 years. CONCLUSIONS: These data suggest that H. pylori infection might be an important risk factor for carotid atherosclerosis in young Chinese males under 50.
Authors: Igor Brasil-Costa; Cintya de Oliveira Souza; Leni Célia Reis Monteiro; Maria Elisabete Silva Santos; Edivaldo Herculano Correa De Oliveira; Rommel Mario Rodriguez Burbano Journal: Pathogens Date: 2022-03-29
Authors: Xiujuan Xia; Linfang Zhang; Hao Wu; Feng Chen; Xuanyou Liu; Huifang Xu; Yuqi Cui; Qiang Zhu; Meifang Wang; Hong Hao; De-Pei Li; William P Fay; Luis A Martinez-Lemus; Michael A Hill; Canxia Xu; Zhenguo Liu Journal: Front Cardiovasc Med Date: 2022-03-31