Koustav Chatterjee1, Akash Roy2, Rebecca Banerjee1, Supriyo Choudhury1, Banashree Mondal1, Saptak Halder1, Purba Basu1, Shantanu Shubham1, Sanjit Dey3, Hrishikesh Kumar4. 1. Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. 2. Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India. 3. Department of Physiology, University of Calcutta, Kolkata, India; Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, Kolkata, India. 4. Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. Electronic address: rishi_medicine@yahoo.com.
Abstract
BACKGROUND: Alpha-synuclein and inflammatory pathology are evident in Parkinson's disease (PD) but, their link to disease pathogenesis needs further elucidation. OBJECTIVES: To explore α-synuclein-mediated inflammation in the serum of PD patients and its link with disease severity. METHODS: Serum levels of IL-1β, NLRP3, total and phosphorylated α-synuclein were compared. RESULTS: IL-1β, NLRP3 levels were significantly increased in PD. We also observed a linear correlation of NLRP3 with α-synuclein. Phosphorylated α-synuclein levels were significantly elevated in later stages of PD. CONCLUSIONS: The α-synuclein-NLRP3 mediated inflammation may underline the pathophysiology of PD and might serve as a novel therapeutic target in PD.
BACKGROUND:Alpha-synuclein and inflammatory pathology are evident in Parkinson's disease (PD) but, their link to disease pathogenesis needs further elucidation. OBJECTIVES: To explore α-synuclein-mediated inflammation in the serum of PDpatients and its link with disease severity. METHODS: Serum levels of IL-1β, NLRP3, total and phosphorylated α-synuclein were compared. RESULTS: IL-1β, NLRP3 levels were significantly increased in PD. We also observed a linear correlation of NLRP3 with α-synuclein. Phosphorylated α-synuclein levels were significantly elevated in later stages of PD. CONCLUSIONS: The α-synuclein-NLRP3 mediated inflammation may underline the pathophysiology of PD and might serve as a novel therapeutic target in PD.
Authors: Fillipe Mendes De Araújo; Annyta Fernandes Frota; Lívia Bacelar de Jesus; Ticiane Caribe Macedo; Lorena Cuenca-Bermejo; Consuelo Sanchez-Rodrigo; Kariny Maria Silva Ferreira; Juciele Valéria Ribeiro de Oliveira; Maria de Fatima Dias Costa; Juan Segura-Aguilar; Silvia Lima Costa; Maria Trinidad Herrero; Victor Diógenes Amaral Silva Journal: Cell Mol Neurobiol Date: 2022-01-06 Impact factor: 5.046
Authors: Fillipe M de Araújo; Lorena Cuenca-Bermejo; Emiliano Fernández-Villalba; Silvia L Costa; Victor Diogenes A Silva; Maria Trinidad Herrero Journal: Cell Mol Neurobiol Date: 2021-01-02 Impact factor: 5.046