Luis A Ruiz1, Leyre Serrano2, Pedro P España3, Lorea Martinez-Indart4, Ainhoa Gómez2, Ane Uranga3, Sonia Castro2, Amaia Artaraz3, Rafael Zalacain2. 1. Pneumology Service, Hospital Universitario Cruces, E-48903 Barakaldo, Bizkaia, Spain. Electronic address: luisalberto.ruiziturriaga@osakidetza.eus. 2. Pneumology Service, Hospital Universitario Cruces, E-48903 Barakaldo, Bizkaia, Spain. 3. Pneumology Service, Hospital Galdakao-Usansolo, Galdakao, Bizkaia, Spain. 4. Bioinformatics and Statistics Unit, Bio-Cruces Bizkaia Health Research Institute, Spain.
Abstract
OBJECTIVE: To assess survival and identify predictors of survival more than 30-days after discharge in a cohort of consecutive patients diagnosed with pneumococcal pneumonia. METHODS: Observational study including all consecutive immunocompetent adult patients surviving more than 30-days after hospitalization. The bacteriological diagnosis was based on the results of urinary antigen testing and/or blood culture. Life expectancy was calculated for each patient considering their sex, age and date of discharge. RESULTS: We included 1114 patients that survived more than 30- days after discharge. Of them, 431 (38.6%) died during follow-up (median follow-up of 6.7 years). Age, history of cancer, liver disease, chronic renal disease, chronic obstructive pulmonary disease, cerebrovascular disease, atrial arrhythmia and coronary disease, red cell distribution width (RDW) > 15%, positive blood culture, hematocrit < 30% and living in a nursing home were independent risk factors for reduced long-term survival after hospital discharge. Cumulative 1-, 3- and 5-year survival rates were 93.9%, 85.3% and 76%, respectively. Among non-survivors, 361 (83.8%) died earlier than expected given their life expectancy. CONCLUSIONS: Survival after hospital discharge is mainly associated with age and comorbidities. The findings of bacteremia and elevated RDW on admission could help identify patients at high risk of long-term mortality.
OBJECTIVE: To assess survival and identify predictors of survival more than 30-days after discharge in a cohort of consecutive patients diagnosed with pneumococcal pneumonia. METHODS: Observational study including all consecutive immunocompetent adult patients surviving more than 30-days after hospitalization. The bacteriological diagnosis was based on the results of urinary antigen testing and/or blood culture. Life expectancy was calculated for each patient considering their sex, age and date of discharge. RESULTS: We included 1114 patients that survived more than 30- days after discharge. Of them, 431 (38.6%) died during follow-up (median follow-up of 6.7 years). Age, history of cancer, liver disease, chronic renal disease, chronic obstructive pulmonary disease, cerebrovascular disease, atrial arrhythmia and coronary disease, red cell distribution width (RDW) > 15%, positive blood culture, hematocrit < 30% and living in a nursing home were independent risk factors for reduced long-term survival after hospital discharge. Cumulative 1-, 3- and 5-year survival rates were 93.9%, 85.3% and 76%, respectively. Among non-survivors, 361 (83.8%) died earlier than expected given their life expectancy. CONCLUSIONS: Survival after hospital discharge is mainly associated with age and comorbidities. The findings of bacteremia and elevated RDW on admission could help identify patients at high risk of long-term mortality.
Authors: Leyre Serrano Fernández; Luis Alberto Ruiz Iturriaga; Pedro Pablo España Yandiola; Raúl Méndez Ocaña; Silvia Pérez Fernández; Eva Tabernero Huget; Ane Uranga Echeverria; Paula Gonzalez Jimenez; Patricia García Hontoria; Antoni Torres Martí; Rosario Menendez Villanueva; Rafael Zalacain Jorge Journal: Int J Infect Dis Date: 2021-11-18 Impact factor: 12.074
Authors: Lara Loreggian; Elena Tagliabue; Filippo Giorgini; Ahmed S Zakaria; Marco Fanchini; Annamaria Veronelli; Antonio E Pontiroli Journal: Sci Rep Date: 2022-06-25 Impact factor: 4.996
Authors: Hector F Africano; Cristian C Serrano-Mayorga; Paula C Ramirez-Valbuena; Ingrid G Bustos; Alirio Bastidas; Hernan A Vargas; Sandra Gómez; Alejandro Rodriguez; Carlos J Orihuela; Luis F Reyes Journal: Clin Infect Dis Date: 2021-06-01 Impact factor: 9.079