Literature DB >> 31703845

Nonpathogenic Bacteria as Targets in Antimicrobial High-Throughput Screening.

Paula Yagüe1, Nathaly Gonzalez-Quiñonez1, Angel Manteca2.   

Abstract

Antimicrobial screening usually analyses the effects of natural or synthetic molecules against pathogens. McAuley et al. changed this paradigm, testing the effect of synthetic compounds against the sporulation of the nonpathogenic bacterium Streptomyces venezuelae. They discovered a novel DNA-targeting antibiotic effective against pathogens.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Streptomyces; antimicrobials; high-throughput screening; sporulation

Year:  2019        PMID： 31703845      PMCID： PMC6978137          DOI： 10.1016/j.tim.2019.10.005

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  4 in total

Review 1.  Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere?

Authors:  Dagmara Jakimowicz; Gilles P van Wezel
Journal:  Mol Microbiol       Date:  2012-06-11       Impact factor: 3.501

Review 2.  The re-emerging role of microbial natural products in antibiotic discovery.

Authors:  Olga Genilloud
Journal:  Antonie Van Leeuwenhoek       Date:  2014-06-13       Impact factor: 2.271

Review 3.  Antibiotics for emerging pathogens.

Authors:  Michael A Fischbach; Christopher T Walsh
Journal:  Science       Date:  2009-08-28       Impact factor: 47.728

4.  Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.

Authors:  Scott McAuley; Alan Huynh; Alison Howells; Chris Walpole; Anthony Maxwell; Justin R Nodwell
Journal:  Cell Chem Biol       Date:  2019-07-03       Impact factor: 8.116
  4 in total

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