Tobias Boeselt1, Rembert Koczulla2, Christoph Nell3, Bjoern Beutel4, Konrad Guenter5, Werner Cassel6, Olaf Hildebrandt7, Ulrich Koehler8, Johannes Kroenig9. 1. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: tobias.boeselt@uni-marburg.de. 2. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany; Pulmonology Schoen Clinic Berchtesgadener Land, Teaching Hospital of Philipps-University of Marburg, Germany. Electronic address: rkoczulla@schoen-klinik.de. 3. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: christoph.nell@googlemail.com. 4. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: beutelb@med.uni-marburg.de. 5. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: konrad.guenter@hotmail.de. 6. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: cassel@staff.uni-marburg.de. 7. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: olaf.hildebrandt@med.uni-marburg.de. 8. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: koehleru@staff.uni-marburg.de. 9. Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: kroenig@med.uni-marburg.de.
Abstract
This review article discusses various forms of sleep disorders associated with musculoskeletal diseases (MD). It presents the pathophysiology and interaction of sleep-related disorders and MD and summarizes clinical symptoms and therapies from a somnological perspective. BACKGROUND: A large number of patients suffering from MD report fragmented sleep with poor overall sleep quality. Sleep disorders often lead to increased symptoms such as daytime fatigue, depression, or increased pain intensity. In contrast, the perception of pain worsens the quality of sleep. Sleep is a complex regulation of hormonal and neuromodulatory influences to maintain regenerative processes and signal processing. Furthermore, interleukins (e.g., IL-6 and TNFα), messenger substances, or inflammatory markers (e.g., CRP) may have a regulatory influence on sleep. THERAPY: Sleep disorders in MD can often be treated with behavioral therapies or drug approaches. Another and very important influence is physical activity. In combination with training, regular physical activity can lead, for instance, to improved sleep quality, endurance performance, and reduced inflammation values. The change of lifestyle with regard to activity and nutrition is another key concept in the optimal therapy of patients with MD.
This review article discusses various forms of sleep disorders associated with musculoskeletal diseases (MD). It presents the pathophysiology and interaction of sleep-related disorders and MD and summarizes clinical symptoms and therapies from a somnological perspective. BACKGROUND: A large number of patients suffering from MD report fragmented sleep with poor overall sleep quality. Sleep disorders often lead to increased symptoms such as daytime fatigue, depression, or increased pain intensity. In contrast, the perception of pain worsens the quality of sleep. Sleep is a complex regulation of hormonal and neuromodulatory influences to maintain regenerative processes and signal processing. Furthermore, interleukins (e.g., IL-6 and TNFα), messenger substances, or inflammatory markers (e.g., CRP) may have a regulatory influence on sleep. THERAPY: Sleep disorders in MD can often be treated with behavioral therapies or drug approaches. Another and very important influence is physical activity. In combination with training, regular physical activity can lead, for instance, to improved sleep quality, endurance performance, and reduced inflammation values. The change of lifestyle with regard to activity and nutrition is another key concept in the optimal therapy of patients with MD.
Authors: Wei-Dong Lai; Dian-Ming Li; Jie Yu; Lin Huang; Ming-Zhi Zheng; Yue-Peng Jiang; Song Wang; Jun-Jun Wen; Si-Jia Chen; Cheng-Ping Wen; Yan Jin Journal: Front Pain Res (Lausanne) Date: 2022-07-25