Literature DB >> 31701855

Continuation of Dual Antiplatelet Therapy in a Patient with a Coronary Artery Stent with Dengue Hemorrhagic Fever: A Clinical Conundrum.

N D B Ehelepola1, A A S D Athurupana1, P G C S Bowatte1, Wasantha P Dissanayake1.   

Abstract

Severe thrombocytopenia with impairment of the activity of platelets and impairment of blood clotting occurs in dengue hemorrhagic fever (DHF). Continuation of dual antiplatelet therapy in such patients can result in life-threatening hemorrhages. On the other hand, withholding of antiplatelets in a patient undergone coronary stenting lately can lead to stent thrombosis, resulting in myocardial infarctions and sudden cardiac death. There are no guidelines on management of DHF in patients with coronary stents. Here, we discuss about several divergent factors that need to be considered and balanced when managing such patients. We describe a case as an example to illustrate how we balanced the risk of serious bleeding versus the risk of stent thrombosis successfully according to evolution of the disease process, by temporary withholding of antiplatelets in such a patient.

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Year:  2020        PMID: 31701855      PMCID: PMC6947787          DOI: 10.4269/ajtmh.19-0512

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  16 in total

1.  Dengue: cardiac manifestations and implications in antithrombotic treatment.

Authors:  Antonio Eduardo Pesaro; Elbio D'Amico; Luis Fernando C Aranha
Journal:  Arq Bras Cardiol       Date:  2007-08       Impact factor: 2.000

2.  Rebound thrombocytosis causing MI following dengue fever?

Authors:  Roy A; Yadav R; Bhargava B; Goswami Kc
Journal:  Indian Heart J       Date:  2007 Jan-Feb

3.  Reversal of the anti-platelet effects of aspirin and clopidogrel.

Authors:  C Li; J Hirsh; C Xie; M A Johnston; J W Eikelboom
Journal:  J Thromb Haemost       Date:  2012-04       Impact factor: 5.824

Review 4.  Perioperative management of patients with drug-eluting stents.

Authors:  Ali O Abualsaud; Mark J Eisenberg
Journal:  JACC Cardiovasc Interv       Date:  2010-02       Impact factor: 11.195

5.  Prophylactic and therapeutic interventions for bleeding in dengue: a systematic review.

Authors:  Senaka Rajapakse; Nipun Lakshitha de Silva; Praveen Weeratunga; Chaturaka Rodrigo; Sumadhya Deepika Fernando
Journal:  Trans R Soc Trop Med Hyg       Date:  2017-10-01       Impact factor: 2.184

Review 6.  Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis.

Authors:  A I Schafer
Journal:  J Clin Pharmacol       Date:  1995-03       Impact factor: 3.126

Review 7.  Growing epidemic of coronary heart disease in low- and middle-income countries.

Authors:  Thomas A Gaziano; Asaf Bitton; Shuchi Anand; Shafika Abrahams-Gessel; Adrianna Murphy
Journal:  Curr Probl Cardiol       Date:  2010-02       Impact factor: 5.200

8.  A dengue infection without bleeding manifestations in an adult with immune thrombocytopenic purpura.

Authors:  N D B Ehelepola; M B K Gunawardhana; T N Sudusinghe; S K D Sooriyaarachchi; S P Manchanayake; K L R Kalupahana
Journal:  Trop Med Health       Date:  2016-11-07

Review 9.  Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014.

Authors:  Robert A Byrne; Michael Joner; Adnan Kastrati
Journal:  Eur Heart J       Date:  2015-09-28       Impact factor: 29.983

10.  Reduced thrombin formation and excessive fibrinolysis are associated with bleeding complications in patients with dengue fever: a case-control study comparing dengue fever patients with and without bleeding manifestations.

Authors:  Fernanda A Orsi; Rodrigo N Angerami; Bruna M Mazetto; Susan K P Quaino; Fernanda Santiago-Bassora; Vagner Castro; Erich V de Paula; Joyce M Annichino-Bizzacchi
Journal:  BMC Infect Dis       Date:  2013-07-28       Impact factor: 3.090

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  1 in total

1.  Peripheral Follicular T Helper Cells and Mucosal-Associated Invariant T Cells Represent Activated Phenotypes During the Febrile Phase of Acute Dengue Virus Infection.

Authors:  Sathappan U Preeyaa; Amudhan Murugesan; Surliappan Sopnajothi; Yean K Yong; Hong Y Tan; Marie Larsson; Vijayakumar Velu; Esaki M Shankar
Journal:  Viral Immunol       Date:  2020-09-30       Impact factor: 2.257

  1 in total

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