Literature DB >> 31701172

Suspected seizure-survival of a lethal dose of the rodenticide alpha-chloralose.

Sebastian Bergrath1,2, Jessika Stefanie Castillo-Vargas3, Nurcihan Joy Koc3, Hendrik Haake4, Ullrich Graeven5.   

Abstract

A 58-year-old female was admitted due to a suspected seizure. A blue colored pharyngeal fluid was visualized during intubation, which is indicative of poisoning. Clinical research revealed an ingestion of 2.4 g of alpha-chloralose, a rodenticide with a lethal dose of 1 g. Immediate detoxification by gastroscopy, gastric lavage and hemodialysis led to full recovery. Substance detection was carried out by gas chromatography-mass spectometry of a urine sample. There are only a few cases reporting poisoning by this substance. Coma and bilateral myoclonus have been reported but blue gastric fluid as the "red flag" in this case has never been described.

Entities:  

Keywords:  Alpha-chloralose; Emergency department; Intoxication; Resuscitation room; Seizure

Year:  2019        PMID： 31701172     DOI： 10.1007/s00101-019-00692-7

Source DB:  PubMed          Journal:  Anaesthesist        ISSN： 0003-2417            Impact factor:   1.041


  9 in total

1.  Resuscitation room management of critically ill nontraumatic patients in a German emergency department (OBSERvE-study).

Authors:  Michael Bernhard; Stephanie Döll; Thomas Hartwig; Alexandra Ramshorn-Zimmer; Maryam Yahiaoui-Doktor; Lorenz Weidhase; Sirak Petros; André Gries
Journal:  Eur J Emerg Med       Date:  2018-08       Impact factor: 2.799

2.  Retained drugs in the gastrointestinal tracts of deceased victims of oral drug overdose.

Authors:  Z Livshits; B A Sampson; M A Howland; R S Hoffman; L S Nelson
Journal:  Clin Toxicol (Phila)       Date:  2014-12-30       Impact factor: 4.467

3.  Testing for alpha-chloralose by headspace-GC/MS. A case report.

Authors:  P Kintz; S Doray; V Cirimele; B Ludes
Journal:  Forensic Sci Int       Date:  1999-09-30       Impact factor: 2.395

4.  1H NMR spectroscopy and GC-MS analysis of alpha-chloralose. Application to two poisoning cases.

Authors:  Sandrine Savin; Bernard Cartigny; Nathalie Azaroual; Luc Humbert; Michel Imbenotte; Djamel Tsouria; Gaston Vermeersch; Michel Lhermitte
Journal:  J Anal Toxicol       Date:  2003-04       Impact factor: 3.367

5.  [Severe chloralose intoxication in a toddler].

Authors:  S Federici; I Claudet; E Laporte-Turpin; M O Marcoux; E Cheuret; K Maréchal
Journal:  Arch Pediatr       Date:  2006-03-13       Impact factor: 1.180

6.  Acute pesticide poisoning in England and Wales.

Authors:  T J Vale; T J Meredith; B M Buckley
Journal:  Health Trends       Date:  1987-02

7.  Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline.

Authors:  Paul E Stevens; Adeera Levin
Journal:  Ann Intern Med       Date:  2013-06-04       Impact factor: 25.391

8.  The toxic effects of alpha-chloralose.

Authors:  H M Thomas; D Simpson; L F Prescott
Journal:  Hum Toxicol       Date:  1988-05

9.  Distribution of chloralose in a fatal intoxication.

Authors:  E Gerace; V Ciccotelli; P Rapetti; A Salomone; M Vincenti
Journal:  J Anal Toxicol       Date:  2012-05-09       Impact factor: 3.367
  9 in total
  3 in total

1.  Alpha-chloralose poisoning in cats in three Nordic countries - the importance of secondary poisoning.

Authors:  Ulrika Windahl; Annica Tevell Åberg; Fedor Kryuchkov; Sandra Lundgren; Cecilia Tegner; Kristoffer Dreimanis; Sanna Koivisto; Outi Simola; Morten Sandvik; Aksel Bernhoft
Journal:  BMC Vet Res       Date:  2022-09-05       Impact factor: 2.792

2.  Alpha-chloralose poisoning in cats: clinical findings in 25 confirmed and 78 suspected cases.

Authors:  Cecilia Tegner; Sandra Lundgren; Kristoffer Dreimanis; Annica Tevell Åberg; Ulrika Windahl
Journal:  J Feline Med Surg       Date:  2022-06-27       Impact factor: 1.971

3.  Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning.

Authors:  Ulrika Windahl; Sandra Lundgren; Margareta Sprycha; Cecilia Tegner; Kristoffer Dreimanis; Annica Tevell Åberg
Journal:  J Anal Toxicol       Date:  2022-07-14       Impact factor: 3.220
  3 in total

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