Jun-Seob Song1, Ki-Taek Hong1, Na-Min Kim1, Jae-Yub Jung1, Han-Soo Park1, Yoo-Chang Kim2, Asode Ananthram Shetty3, Seok Jung Kim2. 1. Department of Orthopaedic Surgery, Seoul JS Hospital, Seoul, Republic of Korea. 2. Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 3. Canterbury Christ Church University, Faculty of Health and Social Sciences, 30 Pembroke Court, Chatham Maritime, Kent, ME4 4UF, United Kingdom.
Abstract
BACKGROUND: Osteochondritis dissecans (OCD) is a pathologic condition accompanied by the gradual destruction of subchondral bone and defects in the overlying articular cartilage.This case series reports the results of allogenic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation for the treatment of osteochondral defect in two cases of juvenile osteochondritis dissecans. CASE PRESENTATION: Two patients with osteochondral defect of the knee recovered from the disease enough to begin major exercise 1 year after hUCB-MSCs implantation. The IKDC, VAS, and Tegner score of the two patients showed an excellent improvement and concurrent arthroscopy was performed; cartilage regeneration of ICRS grade 1 similar to normal was observed. The modified two-dimensional MOCART scores increased in both cases over time. CONCLUSION: This is the first case series detailing the results of treating juvenile OCD lesions using hUCB-MSCs. This could be an option for treating juvenile OCD.
BACKGROUND: Osteochondritis dissecans (OCD) is a pathologic condition accompanied by the gradual destruction of subchondral bone and defects in the overlying articular cartilage.This case series reports the results of allogenic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation for the treatment of osteochondral defect in two cases of juvenile osteochondritis dissecans. CASE PRESENTATION: Two patients with osteochondral defect of the knee recovered from the disease enough to begin major exercise 1 year after hUCB-MSCs implantation. The IKDC, VAS, and Tegner score of the two patients showed an excellent improvement and concurrent arthroscopy was performed; cartilage regeneration of ICRS grade 1 similar to normal was observed. The modified two-dimensional MOCART scores increased in both cases over time. CONCLUSION: This is the first case series detailing the results of treating juvenile OCD lesions using hUCB-MSCs. This could be an option for treating juvenile OCD.
Authors: Richard Kijowski; Donna G Blankenbaker; Kazuhiko Shinki; Jason P Fine; Ben K Graf; Arthur A De Smet Journal: Radiology Date: 2008-06-13 Impact factor: 11.105
Authors: Ellison D Aldrich; Xiaolin Cui; Caroline A Murphy; Khoon S Lim; Gary J Hooper; C Wayne McIlwraith; Tim B F Woodfield Journal: Stem Cells Transl Med Date: 2021-08-13 Impact factor: 6.940