Literature DB >> 31699204

[β Amyloid Hypothesis in Alzheimer's Disease:Pathogenesis,Prevention,and Management].

He Zhang1, Yan Zheng1.   

Abstract

Alzheimer's disease(AD)is a central nervous system disease characterized by progressive cognitive dysfunction and memory loss.Increasing evidences suggest that β amyloid(Aβ)plays a critical role and may be a upstream molecule in AD pathogenesis involving both genetic and environmental factors.Aβ accumulation and its related inflammation are considered early events preceding neurodegeneration and neuronal loss in AD brain.However,all strategies and compounds targeting Aβ deposition have failed in clinical trials,implying complexity of AD pathogenesis.This article reviews Aβ hypothesis and its related mechanisms,pathophysiological process,and therapeutics of AD.

Entities:  

Keywords:  Alzheimer’s disease; Tau protein; inflammation; β amyloid

Mesh：

Substances：

Year:  2019        PMID： 31699204     DOI： 10.3881/j.issn.1000-503X.10875

Source DB:  PubMed          Journal:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao        ISSN： 1000-503X


  13 in total

1.  Amentoflavone Ameliorates Memory Deficits and Abnormal Autophagy in Aβ25-35-Induced Mice by mTOR Signaling.

Authors:  Bing Cao; Mengnan Zeng; Qinqin Zhang; Beibei Zhang; Yangang Cao; Yuanyuan Wu; Weisheng Feng; Xiaoke Zheng
Journal:  Neurochem Res       Date:  2021-01-25       Impact factor: 3.996

2.  Phenylethanoid Glycosides of Cistanche Improve Learning and Memory Disorders in APP/PS1 Mice by Regulating Glial Cell Activation and Inhibiting TLR4/NF-κB Signaling Pathway.

Authors:  Chunhui Wang; Hongxia Ye; Yanjie Zheng; Yanqiang Qi; Mengyu Zhang; Yan Long; Yanli Hu
Journal:  Neuromolecular Med       Date:  2022-07-04       Impact factor: 3.843

Review 3.  Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease Complicated With Osteoporosis.

Authors:  Weifan Xu; Yiping Jiang; Nani Wang; Huanhuan Bai; Shengyan Xu; Tianshuang Xia; Hailiang Xin
Journal:  Front Pharmacol       Date:  2022-06-01       Impact factor: 5.988

4.  Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ1‑40‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system.

Authors:  Bin Li; Pei-Jun Xie; Yan-Wei Hao; Yu Guo; Jun-Rong Yu; Dao-Yin Gong; Jing Guo; Jin-Hao Zeng; Yi Zhang
Journal:  Mol Med Rep       Date:  2021-02-19       Impact factor: 2.952

5.  The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats.

Authors:  Mayila Tuerxun; Ajar Muhda; Lixin Yin
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

Review 6.  Tiny Toes to Tau Tangles: Down's Syndrome and Its Association With Alzheimer's Disease.

Authors:  Sri Madhurima Puttagunta; Rabia Islam; Sumana Kundu; Surajkumar B Jha; Ana P Rivera; Gabriela Vanessa Flores Monar; Hamza Islam; Ibrahim Sange
Journal:  Cureus       Date:  2022-02-11

Review 7.  Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases.

Authors:  Yanling Li; Tingting Zhao; Jiaxin Li; Mengyao Xia; Yuling Li; Xiaoyu Wang; Chuanguo Liu; Tingting Zheng; Renjie Chen; Dongfang Kan; Yicheng Xie; Jingjie Song; Yu Feng; Tiangui Yu; Peng Sun
Journal:  J Immunol Res       Date:  2022-03-23       Impact factor: 4.818

8.  Intelligent Algorithm-Based Quantitative Electroencephalography in Evaluating Cerebral Small Vessel Disease Complicated by Cognitive Impairment.

Authors:  Hengya Zhu; Jingjing Qiu; Xiaoyan Sun; Xiangyan Yang; Bin Zhang; Ying Tan
Journal:  Comput Math Methods Med       Date:  2022-01-29       Impact factor: 2.238

9.  Effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease and sleep disorder: A randomized controlled trial.

Authors:  Shuyu Huo; Lin Cheng; Shuying Li; Fulu Xu
Journal:  Brain Behav       Date:  2022-01-18       Impact factor: 2.708

Review 10.  Dapsone, More than an Effective Neuro and Cytoprotective Drug.

Authors:  Araceli Diaz-Ruiz; Juan Nader-Kawachi; Francisco Calderón-Estrella; Alfonso Mata-Bermudez; Laura Alvarez-Mejia; Camilo Ríos
Journal:  Curr Neuropharmacol       Date:  2022       Impact factor: 7.708
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