María Lorenzo-González1, Alberto Ruano-Ravina2, María Torres-Durán3, Mariano Provencio-Pulla4, Karl Kelsey5, Isaura Parente-Lamelas6, Iria Vidal-García7, Virginia Leiro-Fernández3, Cristina Martínez8, Jesús Hernández9, Olalla Castro-Añón10, Silvia García-García11, Paula Sales-Fidalgo12, José Abal-Arca6, Carmen Montero-Martínez7, Mónica Pérez-Ríos13, Alberto Fernández-Villar3, Juan Miguel Barros-Dios14. 1. Service of Preventive Medicine, University Hospital Complex of Ourense, Spain; Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain. 2. Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; CIBER de Epidemiología y Salud Pública CIBERESP, Spain. Electronic address: alberto.ruano@usc.es. 3. Service of Neumology, University Hospital Complex of Vigo, Spain. 4. Service of Oncology, Puerta de Hierro University Hospital, Madrid, Spain. 5. Department of Epidemiology, Brown University, USA. 6. Service of Neumology, University Hospital Complex of Ourense, Spain. 7. Service of Neumology, University Hospital Complex of A Coruña, Spain. 8. National Institute of Silicosis, University Hospital of Asturias, Oviedo, Spain. 9. Service of Neumology, University Hospital Complex of Ávila, Spain. 10. Service of Neumology, Hospital Lucus Augusti, Lugo, Spain. 11. Service of Neumology, University Hospital Complex of Leon, Spain. 12. Serviço de Oncologia Médica Centro Hospitalar do Porto, Portugal. 13. Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; CIBER de Epidemiología y Salud Pública CIBERESP, Spain. 14. Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; CIBER de Epidemiología y Salud Pública CIBERESP, Spain; Service of Preventive Medicine, University Hospital Complex of Santiago de Compostela, Spain.
Abstract
BACKGROUND: The aim of this study was to assess the relationship between do-it-yourself activities entailing the exposure to carcinogenic substances and the risk of lung cancer. METHODS: We pooled individual data from different case-control studies conducted in Northwestern Spain which investigated residential radon and lung cancer. Cases had an anatomopathologically confirmed primary lung cancer and controls were selected at the pre-surgery unit with uncomplicated surgeries. Both cases and controls were older than 30 years with no previous cancer history. All participants were interviewed face-to-face using a specific questionnaire. Painting, model building, furniture refinishing and woodworking or home carpentry were the do-it-yourself activities considered risky due to exposure to carcinogenic agents. RESULTS: We included 1528 cases and 1457 controls. Practicing do-it-yourself risk activities was more frequent among cases: 16.0% were exposed to carcinogenic exposures during leisure time, compared to 11.8% for controls. The overall adjusted OR for lung cancer risk among individuals who practiced do-it-yourself risk activities, was 1.77 (95% CI: 1.36-2.31); this was 2.17 (95% CI: 1.51-3.11) when the analysis was restricted to individuals who performed these activities for at least 10 years. These risks were greater when the analyses were carried out exclusively among never-smokers, with the respective ORs being 2.04 (95% CI: 1.38-3.01) and 3.10 (95% CI: 1.78-5.40). CONCLUSION: These results support the hypothesis that do-it-yourself activities involving exposure to certain carcinogens are associated with an increased risk of lung cancer, both in ever and never-smokers.
BACKGROUND: The aim of this study was to assess the relationship between do-it-yourself activities entailing the exposure to carcinogenic substances and the risk of lung cancer. METHODS: We pooled individual data from different case-control studies conducted in Northwestern Spain which investigated residential radon and lung cancer. Cases had an anatomopathologically confirmed primary lung cancer and controls were selected at the pre-surgery unit with uncomplicated surgeries. Both cases and controls were older than 30 years with no previous cancer history. All participants were interviewed face-to-face using a specific questionnaire. Painting, model building, furniture refinishing and woodworking or home carpentry were the do-it-yourself activities considered risky due to exposure to carcinogenic agents. RESULTS: We included 1528 cases and 1457 controls. Practicing do-it-yourself risk activities was more frequent among cases: 16.0% were exposed to carcinogenic exposures during leisure time, compared to 11.8% for controls. The overall adjusted OR for lung cancer risk among individuals who practiced do-it-yourself risk activities, was 1.77 (95% CI: 1.36-2.31); this was 2.17 (95% CI: 1.51-3.11) when the analysis was restricted to individuals who performed these activities for at least 10 years. These risks were greater when the analyses were carried out exclusively among never-smokers, with the respective ORs being 2.04 (95% CI: 1.38-3.01) and 3.10 (95% CI: 1.78-5.40). CONCLUSION: These results support the hypothesis that do-it-yourself activities involving exposure to certain carcinogens are associated with an increased risk of lung cancer, both in ever and never-smokers.
Authors: Alexandra Giraldo-Osorio; Alberto Ruano-Ravina; Mónica Pérez-Ríos; Leonor Varela-Lema; Juan Miguel Barros-Dios; Nelson Enrique Arias-Ortiz Journal: Int J Environ Res Public Health Date: 2021-01-29 Impact factor: 3.390
Authors: Haifeng Li; Jingwen Guo; Hongsen Liang; Ting Zhang; Jinyu Zhang; Li Wei; Donglei Shi; Junhang Zhang; Zhaojun Wang Journal: Front Public Health Date: 2022-06-17