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Literature DB >> 3169734

A new rare distamycin A-inducible fragile site, fra(11) (p15.1), found in two acute nonlymphocytic leukemia (ANLL) patients with t(7;11)(p15-p13;p15).

E Takahashi¹, Y Kaneko, T Ishihara, M Minamihisamatsu, M Murata, T Hori.

Abstract

Fragile sites were analyzed in normal peripheral lymphocytes from two acute nonlymphocytic leukemia patients with t(7;11)(p15-p13;p15) leukemic cells. To induce expression of fragile sites, cultures were exposed to folate deprivation (M-F10), BrdU, distamycin A, or Hoechst 33258. Fragility at 11p15.1 was induced by distamycin A and Hoechst 33258 but was not seen in M-F10, BrdU, and control cultures. Fra(11)(p15.1) was found neither in healthy Japanese subjects (0 in 845) nor in patients with leukemia or other hematologic disorders without the t(7;11) (0 in 126). From these results, fra(11)(p15.1) can now be classified as a rare distamycin A-inducible fragile site. Furthermore, this fra(11)(p15.1) coincided with one of the breakpoints of the t(7;11)(p15-p13;p15).

Entities: Chemical Disease Gene Species

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Year: 1988 PMID： 3169734 DOI： 10.1007/bf00702853

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

14 in total

1. Population cytogenetics of rare fragile sites in Japan.

Authors: E Takahashi; T Hori; M Murata
Journal: Hum Genet Date: 1988-02 Impact factor: 4.132

2. Fragile sites and cancer breakpoints--the pessimistic view.

Authors: G R Sutherland
Journal: Cancer Genet Cytogenet Date: 1988-03

3. Translocation t(7;11)(p13;p15) in acute nonlymphocytic leukemia.

Authors: T Ishihara; M Minamihisamatsu; Y Yokoyama
Journal: Cancer Genet Cytogenet Date: 1986-01-15

4. Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites.

Authors: R Berger; C D Bloomfield; G R Sutherland
Journal: Cytogenet Cell Genet Date: 1985

5. Spontaneous expression of fra(11)(q23) in a patient with Ewing's sarcoma and t(11;22)(q23;q11).

Authors: S M Gollin; L J Perrot; B A Gray; M Kletzel
Journal: Cancer Genet Cytogenet Date: 1986-02-15

6. Heritable fragile sites in cancer.

Authors: M M LeBeau; J D Rowley
Journal: Nature Date: 1984 Apr 12-18 Impact factor: 49.962

7. Heritable rare fragile sites in patients with leukemia and other hematologic disorders.

Authors: M Murata; E Takahashi; M Minamihisamatsu; T Ishihara; P Wong; M Bessho; K Hirashima; T Hori
Journal: Cancer Genet Cytogenet Date: 1988-03

8. Further localization of ETS1 indicates that the chromosomal rearrangement in Ewing sarcoma does not occur at fra(11)(q23).

Authors: R N Simmers; G R Sutherland
Journal: Hum Genet Date: 1988-02 Impact factor: 4.132

2. Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice.

Authors: A Silver; R Cox
Journal: Proc Natl Acad Sci U S A Date: 1993-02-15 Impact factor: 11.205

3. Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review.

Authors: Jingke Yang; Xiaodong Lyu; Xinghu Zhu; Xiangguang Meng; Wenli Zuo; Hao Ai; Mei Deng
Journal: Oncol Lett Date: 2017-03-07 Impact factor: 2.967

3 in total